| 2021-10-30 | ArbroathvDunfermlineChampionship · Scotland | 4–2 | Championship · Scotland |
| 2021-10-30 | Sp LisbonvGuimaraesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-10-30 | AtalantavLazioSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-10-30 | BastiavAmiensLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-10-30 | GrimsbyvNotts CountyNational League · England | 0–1 | National League · England |
| 2021-10-30 | DijonvParis FCLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-10-30 | Univ. CraiovavMioveniSuperliga · Romania | 5–2 | Superliga · Romania |
| 2021-10-30 | LiverpoolvBrightonPremier League · England | 2–2 | Premier League · England |
| 2021-10-30 | LeicestervArsenalPremier League · England | 0–2 | Premier League · England |
| 2021-10-30 | DunkerquevLe HavreLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-10-30 | AlloavAirdrie UtdLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-10-30 | TorinovSampdoriaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-10-30 | TottenhamvMan UnitedPremier League · England | 0–3 | Premier League · England |
| 2021-10-30 | NewcastlevChelseaPremier League · England | 0–3 | Premier League · England |
| 2021-10-30 | StokevCardiffChampionship · England | 3–3 | Championship · England |
| 2021-10-30 | Rubin KazanvCSKA MoscowPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-10-30 | WrexhamvTorquayNational League · England | 1–1 | National League · England |
| 2021-10-30 | NancyvSochauxLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-10-30 | KilmarnockvQueen of SthChampionship · Scotland | 4–0 | Championship · Scotland |
| 2021-10-30 | RodezvQuevilly RouenLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-10-30 | NimesvNiortLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-10-30 | WiganvBurtonLeague One · England | 2–0 | League One · England |
| 2021-10-30 | DerbyvBlackburnChampionship · England | 1–2 | Championship · England |
| 2021-10-30 | ClydevFalkirkLeague One · Scotland | 1–3 | League One · Scotland |
| 2021-10-30 | Flamengo RJvAtletico-MGSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-30 | HullvCoventryChampionship · England | 0–1 | Championship · England |
| 2021-10-30 | PlymouthvIpswichLeague One · England | 2–1 | League One · England |
| 2021-10-30 | Kelty HeartsvStirlingLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-10-30 | SuttonvWalsallLeague Two · England | 0–1 | League Two · England |
| 2021-10-30 | LincolnvShrewsburyLeague One · England | 1–1 | League One · England |
| 2021-10-30 | RiedvSalzburgBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-10-30 | PanetolikosvOlympiakosSuper League · Greece | 1–2 | Super League · Greece |
| 2021-10-30 | DresdenvSandhausen2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-10-30 | Annan AthleticvCowdenbeathLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-10-30 | BielefeldvMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-10-30 | ToulousevGuingampLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-10-30 | Leyton OrientvHartlepoolLeague Two · England | 5–0 | League Two · England |
| 2021-10-30 | OldhamvSwindonLeague Two · England | 1–3 | League Two · England |
| 2021-10-30 | Gornik Z.vZaglebieEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-10-30 | JuarezvPueblaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-10-30 | ValenciavVillarrealLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-10-30 | Man CityvCrystal PalacePremier League · England | 0–2 | Premier League · England |
| 2021-10-30 | EstorilvBenficaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-10-30 | EastleighvMaidenheadNational League · England | 1–0 | National League · England |
| 2021-10-30 | LeverkusenvWolfsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-10-30 | ZurichvBaselSuper League · Switzerland | 3–3 | Super League · Switzerland |
| 2021-10-30 | CambridgevAFC WimbledonLeague One · England | 1–0 | League One · England |
| 2021-10-30 | DortmundvFC KolnBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-10-29 | AlmeriavLeganesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-29 | ZenitvDynamo MoscowPremier League · Russia | 4–1 | Premier League · Russia |