| 2010-09-28 | CardiffvCrystal PalaceChampionship · England | 0–0 | Championship · England |
| 2010-09-28 | Sheffield WedsvOldhamLeague One · England | 0–0 | League One · England |
| 2010-09-28 | HistonvGatesheadNational League · England | 1–3 | National League · England |
| 2010-09-28 | TorquayvAldershotLeague Two · England | 0–1 | League Two · England |
| 2010-09-28 | SwindonvPlymouthLeague One · England | 2–3 | League One · England |
| 2010-09-28 |  French Guianav RéunionCoupe de l'Outre-Mer | 0–1 | Coupe de l'Outre-Mer |
| 2010-09-28 | DerbyvMiddlesbroughChampionship · England | 3–1 | Championship · England |
| 2010-09-28 | LeedsvPrestonChampionship · England | 4–6 | Championship · England |
| 2010-09-28 | Bath CityvKidderminsterNational League · England | 2–0 | National League · England |
| 2010-09-28 | Bristol RvsvTranmereLeague One · England | 0–1 | League One · England |
| 2010-09-28 | Port ValevShrewsburyLeague Two · England | 1–0 | League Two · England |
| 2010-09-28 |  Omanv IranWAFF Championship | 2–2 | WAFF Championship |
| 2010-09-28 | BrightonvBrentfordLeague One · England | 1–0 | League One · England |
| 2010-09-28 | Nott'm ForestvSheffield UnitedChampionship · England | 1–1 | Championship · England |
| 2010-09-28 | QPRvMillwallChampionship · England | 0–0 | Championship · England |
| 2010-09-28 | LutonvMansfieldNational League · England | 2–0 | National League · England |
| 2010-09-28 | CharltonvMilton Keynes DonsLeague One · England | 1–0 | League One · England |
| 2010-09-28 | Newport CountyvForest GreenNational League · England | 3–1 | National League · England |
| 2010-09-28 | SouthportvHayes & YeadingNational League · England | 0–0 | National League · England |
| 2010-09-28 | BarrowvFleetwood TownNational League · England | 0–2 | National League · England |
| 2010-09-28 | BournemouthvExeterLeague One · England | 3–0 | League One · England |
| 2010-09-28 | RotherhamvBradfordLeague Two · England | 0–0 | League Two · England |
| 2010-09-27 | Evian Thonon GaillardvBoulogneLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-09-27 | ModenavTriestinaSerie B · Italy | 2–2 | Serie B · Italy |
| 2010-09-27 | YorkvDarlingtonNational League · England | 0–0 | National League · England |
| 2010-09-27 | SetubalvPacos FerreiraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2010-09-27 | Fortuna DusseldorfvBochum2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-09-27 |  Yemenv PalestineWAFF Championship | 3–1 | WAFF Championship |
| 2010-09-27 | MalagavVillarrealLa Liga · Spain | 2–3 | La Liga · Spain |
| 2010-09-27 | KasimpasavFenerbahceSüper Lig · Turkey | 2–6 | Süper Lig · Turkey |
| 2010-09-26 | SampdoriavUdineseSerie A · Italy | 0–0 | Serie A · Italy |
| 2010-09-26 | PortimonensevBeira MarPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2010-09-26 | Sp LisbonvNacionalPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-09-26 | JuventusvCagliariSerie A · Italy | 4–2 | Serie A · Italy |
| 2010-09-26 |  Guadeloupev TahitiCoupe de l'Outre-Mer | 1–1 p | Coupe de l'Outre-Mer |
| 2010-09-26 | ToulousevLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-09-26 | MallorcavSociedadLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-09-26 | AugsburgvMunich 18602. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2010-09-26 | BoltonvMan UnitedPremier League · England | 2–2 | Premier League · England |
| 2010-09-26 | PalermovLecceSerie A · Italy | 2–2 | Serie A · Italy |
| 2010-09-26 | VVV VenlovGraafschapEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-09-26 | SantandervGetafeLa Liga · Spain | 0–1 | La Liga · Spain |
| 2010-09-26 | IraklisvKavalaSuper League · Greece | 0–1 | Super League · Greece |
| 2010-09-26 | ManisasporvSivassporSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2010-09-26 | BarivBresciaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-09-26 | GerminalvClub BruggePro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-09-26 | WolfsburgvFreiburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-09-26 | ExcelsiorvVitesseEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-09-26 |  BahrainvOmanWAFF Championship | 2–0 | WAFF Championship |
| 2010-09-26 | OberhausenvOsnabruck2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |