| 2021-10-30 | QueretarovSantos LagunaLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2021-10-30 | Crawley TownvPort ValeLeague Two · England | 1–4 | League Two · England |
| 2021-10-30 | MansfieldvTranmereLeague Two · England | 2–0 | League Two · England |
| 2021-10-30 | SiriusvMalmo FFAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-10-30 | CharltonvDoncasterLeague One · England | 4–0 | League One · England |
| 2021-10-30 | Sheffield UnitedvBlackpoolChampionship · England | 0–1 | Championship · England |
| 2021-10-30 | LugovSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-30 | BradfordvForest GreenLeague Two · England | 1–1 | League Two · England |
| 2021-10-30 | HackenvKalmarAllsvenskan · Sweden | 1–4 | Allsvenskan · Sweden |
| 2021-10-30 | PAOKvApollonSuper League · Greece | 4–1 | Super League · Greece |
| 2021-10-30 | AltachvHartbergBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-10-30 | HeerenveenvVitesseEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-10-30 | PortovBoavistaPrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2021-10-30 | GillinghamvAccringtonLeague One · England | 0–0 | League One · England |
| 2021-10-30 | Cove RangersvQueens ParkLeague One · Scotland | 3–3 | League One · Scotland |
| 2021-10-30 | CaenvGrenobleLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-10-30 | St. GallenvYoung BoysSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-10-30 | FulhamvWest BromChampionship · England | 3–0 | Championship · England |
| 2021-10-30 | BarcelonavAlavesLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-30 | Argentinos JrsvLanusLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-30 | Spartak MoscowvFK RostovPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-30 | Raith RvsvAyrChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-10-30 | SalfordvExeterLeague Two · England | 1–2 | League Two · England |
| 2021-10-30 | RotherhamvSunderlandLeague One · England | 5–1 | League One · England |
| 2021-10-30 | HarrogatevBristol RvsLeague Two · England | 0–1 | League Two · England |
| 2021-10-30 | AZ AlkmaarvZwolleEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-10-30 | PrestonvLutonChampionship · England | 2–0 | Championship · England |
| 2021-10-30 | HamburgvHolstein Kiel2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-30 | New York Red BullsvCF MontrealMLS · United States | 1–0 | MLS · United States |
| 2021-10-30 | CharleroivEupenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-10-30 | SolihullvYeovilNational League · England | 0–0 | National League · England |
| 2021-10-30 | HannovervErzgebirge Aue2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-30 | BurnleyvBrentfordPremier League · England | 3–1 | Premier League · England |
| 2021-10-30 | BromleyvHalifaxNational League · England | 0–0 | National League · England |
| 2021-10-30 | MetzvSt EtienneLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-30 | WeymouthvKings LynnNational League · England | 1–0 | National League · England |
| 2021-10-30 | HeraclesvAjaxEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-10-30 | Boreham WoodvSouthendNational League · England | 1–0 | National League · England |
| 2021-10-30 | ReadingvBournemouthChampionship · England | 0–2 | Championship · England |
| 2021-10-30 | SwanseavPeterboroChampionship · England | 3–0 | Championship · England |
| 2021-10-30 | St TruidenvClub BruggePro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-10-30 | BanfieldvVelez SarsfieldLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-30 | CelticvLivingstonPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-10-30 | VarbergvOstersundsAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-10-30 | MiddlesbroughvBirminghamChampionship · England | 0–2 | Championship · England |
| 2021-10-30 | BarrowvRochdaleLeague Two · England | 1–2 | League Two · England |
| 2021-10-30 | Dundee UnitedvSt JohnstonePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-10-30 | Warta PoznanvLechia GdanskEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-10-30 | KonyasporvFenerbahceSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-30 | MortonvHamiltonChampionship · Scotland | 1–1 | Championship · Scotland |