| 2010-10-02 | WaregemvCharleroiPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-10-02 | BurtonvStockportLeague Two · England | 2–1 | League Two · England |
| 2010-10-02 | Dag and RedvSwindonLeague One · England | 2–1 | League One · England |
| 2010-10-02 | PlymouthvHartlepoolLeague One · England | 0–1 | League One · England |
| 2010-10-02 | BarrowvLutonNational League · England | 0–1 | National League · England |
| 2010-10-02 | MonacovBrestLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-10-02 | NAC BredavNijmegenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-10-02 | FenerbahcevGenclerbirligiSüper Lig · Türkiye | 3–0 | Süper Lig · Türkiye |
| 2010-10-02 | NancyvLyonLigue 1 · France | 2–3 | Ligue 1 · France |
| 2010-10-02 | Asteras TripolisvAtromitosSuper League Greece · Greece | 1–1 | Super League Greece · Greece |
| 2010-10-02 | Réunionv MartiniqueCoupe de l'Outre-Mer | 0–0 p | Coupe de l'Outre-Mer |
| 2010-10-02 | SochauxvLensLigue 1 · France | 3–0 | Ligue 1 · France |
| 2010-10-02 | HuescavCeltaLaLiga 2 · Spain | 1–2 | LaLiga 2 · Spain |
| 2010-10-02 | ClydevElginLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2010-10-02 | BrentfordvCharltonLeague One · England | 2–1 | League One · England |
| 2010-10-02 | StokevBlackburnPremier League · England | 1–0 | Premier League · England |
| 2010-10-02 | DarlingtonvWrexhamNational League · England | 0–1 | National League · England |
| 2010-10-02 | HullvCoventryChampionship · England | 0–0 | Championship · England |
| 2010-10-02 | TottenhamvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2010-10-02 | Raith RvsvStirlingChampionship · Scotland | 0–2 | Championship · Scotland |
| 2010-10-02 | West BromvBoltonPremier League · England | 1–1 | Premier League · England |
| 2010-10-02 | OlhanensevSetubalPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-10-02 | BradfordvMorecambeLeague Two · England | 0–1 | League Two · England |
| 2010-10-02 | SwanseavDerbyChampionship · England | 0–0 | Championship · England |
| 2010-10-02 | Sheffield UnitedvWatfordChampionship · England | 0–1 | Championship · England |
| 2010-10-02 | ZaragozavSp GijonLaLiga · Spain | 2–2 | LaLiga · Spain |
| 2010-10-02 | Albion RvsvEast StirlingLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2010-10-02 | GatesheadvMansfieldNational League · England | 1–1 | National League · England |
| 2010-10-02 | ShrewsburyvTorquayLeague Two · England | 1–1 | League Two · England |
| 2010-10-02 | RegginavVicenzaSerie B · Italy | 3–2 | Serie B · Italy |
| 2010-10-02 | Milton Keynes DonsvColchesterLeague One · England | 1–1 | League One · England |
| 2010-10-02 | AldershotvCheltenhamLeague Two · England | 0–2 | League Two · England |
| 2010-10-02 | AltrinchamvRushden & DNational League · England | 2–2 | National League · England |
| 2010-10-02 | BuryvRotherhamLeague Two · England | 1–1 | League Two · England |
| 2010-10-02 | Eastbourne BoroughvYorkNational League · England | 2–1 | National League · England |
| 2010-10-02 | M'gladbachvWolfsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-10-02 | BerwickvAnnan AthleticLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-10-02 | UdinesevCesenaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-10-02 | TorinovPortogruaroSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-10-02 | AFC WimbledonvForest GreenNational League · England | 1–1 | National League · England |
| 2010-10-02 | RecreativovLas PalmasLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |
| 2010-10-02 | Inverness CvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-10-02 | SouthportvTamworthNational League · England | 2–1 | National League · England |
| 2010-10-02 | FreiburgvFC KolnBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2010-10-02 | AlloavForfarLeague One · Scotland | 3–2 | League One · Scotland |
| 2010-10-02 | TranmerevBrightonLeague One · England | 1–1 | League One · England |
| 2010-10-02 | BetisvPonferradinaLaLiga 2 · Spain | 3–0 | LaLiga 2 · Spain |
| 2010-10-02 | DoncastervNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2010-10-02 | GrossetovFrosinoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-10-02 | StevenagevWycombeLeague Two · England | 0–2 | League Two · England |