| 2021-10-30 | St MirrenvDundeePremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-10-30 | WokingvAltrinchamNational League · England | 3–2 | National League · England |
| 2021-10-30 | KrasnodarvKrylya SovetovPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-30 | Bristol CityvBarnsleyChampionship · England | 2–1 | Championship · England |
| 2021-10-30 | ElchevReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-10-30 | CFR ClujvFC VoluntariSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-10-30 | PartickvInverness CChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-10-30 | WatfordvSouthamptonPremier League · England | 0–1 | Premier League · England |
| 2021-10-30 | LyonvLensLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-10-30 | Fleetwood TownvWycombeLeague One · England | 3–3 | League One · England |
| 2021-10-30 | KristiansundvTromsoEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-10-30 | A. KlagenfurtvAdmiraBundesliga · Austria | 3–3 | Bundesliga · Austria |
| 2021-10-30 | HuescavAmorebietaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-30 | AberdeenvHeartsPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-10-30 | PlatensevAtl. TucumanLiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2021-10-30 | Athletico-PRvSantosSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-10-30 | CartagenavPonferradinaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-10-30 | Dover AthleticvStockportNational League · England | 2–5 | National League · England |
| 2021-10-30 | Arsenal SarandivSarmiento JuninLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-30 | VeronavJuventusSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-10-30 | Atlanta UtdvToronto FCMLS · United States | 1–1 | MLS · United States |
| 2021-10-30 | Newport CountyvStevenageLeague Two · England | 5–0 | League Two · England |
| 2021-10-30 | Termalica B-B.vSlask WroclawEkstraklasa · Poland | 4–3 | Ekstraklasa · Poland |
| 2021-10-30 | CrewevMilton Keynes DonsLeague One · England | 1–4 | League One · England |
| 2021-10-30 | HataysporvBesiktasSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-10-30 | JuventudevBahiaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-10-30 | PSV EindhovenvTwenteEredivisie · Netherlands | 5–2 | Eredivisie · Netherlands |
| 2021-10-30 | Pau FCvAjaccioLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-10-30 | Union BerlinvBayern MunichBundesliga · Germany | 2–5 | Bundesliga · Germany |
| 2021-10-30 | SevillavOsasunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-10-30 | East FifevDumbartonLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-10-30 | Werder BremenvSt Pauli2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-30 | Inter MiamivNew York CityMLS · United States | 1–3 | MLS · United States |
| 2021-10-30 | Dag and RedvChesterfieldNational League · England | 2–2 | National League · England |
| 2021-10-30 | FreiburgvGreuther FurthBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-10-30 | CheltenhamvSheffield WedsLeague One · England | 2–2 | League One · England |
| 2021-10-30 | JagielloniavPiast GliwiceEkstraklasa · Poland | 3–3 | Ekstraklasa · Poland |
| 2021-10-30 | RosenborgvLillestromEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-10-30 | Real Salt LakevSan Jose EarthquakesMLS · United States | 3–4 | MLS · United States |
| 2021-10-30 | StandardvKortrijkPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-10-30 | AltayvSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-10-30 | PortsmouthvBoltonLeague One · England | 1–0 | League One · England |
| 2021-10-30 | ColchestervScunthorpeLeague Two · England | 2–1 | League Two · England |
| 2021-10-30 | PeterheadvMontroseLeague One · Scotland | 0–0 | League One · Scotland |
| 2021-10-30 | Ein FrankfurtvRB LeipzigBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-10-30 | HuddersfieldvMillwallChampionship · England | 1–0 | Championship · England |
| 2021-10-30 | BarnetvAldershotNational League · England | 2–1 | National League · England |
| 2021-10-30 | KasimpasavYeni MalatyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-10-30 | OxfordvMorecambeLeague One · England | 3–1 | League One · England |
| 2021-10-30 | StranraervForfarLeague Two · Scotland | 2–3 | League Two · Scotland |