| 2010-10-02 | BrentfordvCharltonLeague One · England | 2–1 | League One · England |
| 2010-10-02 | StokevBlackburnPremier League · England | 1–0 | Premier League · England |
| 2010-10-02 | DarlingtonvWrexhamNational League · England | 0–1 | National League · England |
| 2010-10-02 | HullvCoventryChampionship · England | 0–0 | Championship · England |
| 2010-10-02 | TottenhamvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2010-10-02 | Raith RvsvStirlingChampionship · Scotland | 0–2 | Championship · Scotland |
| 2010-10-02 | West BromvBoltonPremier League · England | 1–1 | Premier League · England |
| 2010-10-02 | OlhanensevSetubalPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-10-02 | BradfordvMorecambeLeague Two · England | 0–1 | League Two · England |
| 2010-10-02 | SwanseavDerbyChampionship · England | 0–0 | Championship · England |
| 2010-10-02 | Sheffield UnitedvWatfordChampionship · England | 0–1 | Championship · England |
| 2010-10-02 | ZaragozavSp GijonLa Liga · Spain | 2–2 | La Liga · Spain |
| 2010-10-02 | Albion RvsvEast StirlingLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2010-10-02 | GatesheadvMansfieldNational League · England | 1–1 | National League · England |
| 2010-10-02 | ShrewsburyvTorquayLeague Two · England | 1–1 | League Two · England |
| 2010-10-02 | RegginavVicenzaSerie B · Italy | 3–2 | Serie B · Italy |
| 2010-10-02 | Milton Keynes DonsvColchesterLeague One · England | 1–1 | League One · England |
| 2010-10-02 | AldershotvCheltenhamLeague Two · England | 0–2 | League Two · England |
| 2010-10-02 | AltrinchamvRushden & DNational League · England | 2–2 | National League · England |
| 2010-10-02 | BuryvRotherhamLeague Two · England | 1–1 | League Two · England |
| 2010-10-02 | Eastbourne BoroughvYorkNational League · England | 2–1 | National League · England |
| 2010-10-02 | M'gladbachvWolfsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-10-02 | BerwickvAnnan AthleticLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-10-02 | UdinesevCesenaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-10-02 | TorinovPortogruaroSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-10-02 | AFC WimbledonvForest GreenNational League · England | 1–1 | National League · England |
| 2010-10-02 | RecreativovLas PalmasLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-10-02 | Inverness CvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-10-02 | SouthportvTamworthNational League · England | 2–1 | National League · England |
| 2010-10-02 | FreiburgvFC KolnBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2010-10-02 | AlloavForfarLeague One · Scotland | 3–2 | League One · Scotland |
| 2010-10-02 | TranmerevBrightonLeague One · England | 1–1 | League One · England |
| 2010-10-02 | BetisvPonferradinaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2010-10-02 | DoncastervNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2010-10-02 | GrossetovFrosinoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-10-02 | StevenagevWycombeLeague Two · England | 0–2 | League Two · England |
| 2010-10-02 | SociedadvEspanolLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-10-02 | BordeauxvLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-10-02 | StranraervMontroseLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2010-10-02 | PrestonvReadingChampionship · England | 1–1 | Championship · England |
| 2010-10-02 | MotherwellvSt MirrenPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2010-10-02 | BirminghamvEvertonPremier League · England | 0–2 | Premier League · England |
| 2010-10-02 | KavalavPanioniosSuper League · Greece | 2–1 | Super League · Greece |
| 2010-10-02 | Crawley TownvKidderminsterNational League · England | 2–0 | National League · England |
| 2010-10-01 | LeiriavAcademicaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2010-10-01 | NimesvLe MansLigue 2 · France | 1–2 | Ligue 2 · France |
| 2010-10-01 | PaderbornvBielefeld2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2010-10-01 | SedanvIstresLigue 2 · France | 5–1 | Ligue 2 · France |
| 2010-10-01 | HannovervSt PauliBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-10-01 |  Iranv IraqWAFF Championship | 2–1 | WAFF Championship |