| 2016-12-22 | CagliarivSassuoloSerie A · Italy | 4–3 | Serie A · Italy |
| 2016-12-22 | Sp BragavMoreirensePrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2016-12-22 | FeirensevPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2016-12-21 | EupenvClub BruggePro League · Belgium | 1–4 | Pro League · Belgium |
| 2016-12-21 | KortrijkvOostendePro League · Belgium | 0–2 | Pro League · Belgium |
| 2016-12-21 | Paris SGvLorientLigue 1 · France | 5–0 | Ligue 1 · France |
| 2016-12-21 | IntervLazioSerie A · Italy | 3–0 | Serie A · Italy |
| 2016-12-21 | HerthavDarmstadtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2016-12-21 | BordeauxvNiceLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-12-21 | StandardvLokerenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2016-12-21 | St EtiennevNancyLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-12-21 | DijonvToulouseLigue 1 · France | 2–0 | Ligue 1 · France |
| 2016-12-21 | MetzvGuingampLigue 1 · France | 2–2 | Ligue 1 · France |
| 2016-12-21 | BastiavMarseilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2016-12-21 | MillwallvCharltonLeague One · England | 3–1 | League One · England |
| 2016-12-21 | IngolstadtvFreiburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2016-12-21 | FC KolnvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-12-21 | HoffenheimvWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-12-21 | NantesvMontpellierLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-12-21 |  MonacovCaenLigue 1 · France | 2–1 | Ligue 1 · France |
| 2016-12-21 | BenficavRio AvePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2016-12-21 | Bayern MunichvRB LeipzigBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2016-12-21 | LyonvAngersLigue 1 · France | 2–0 | Ligue 1 · France |
| 2016-12-21 | WaregemvGenkPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-12-21 | LillevRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-12-20 | MouscronvWesterloPro League · Belgium | 0–0 | Pro League · Belgium |
| 2016-12-20 | AtalantavEmpoliSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-12-20 | CelticvPartickPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2016-12-20 | Ein FrankfurtvMainzBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2016-12-20 | TigrevAtl. TucumanLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2016-12-20 | StenhousemuirvEast FifeLeague One · Scotland | 0–1 | League One · Scotland |
| 2016-12-20 | M'gladbachvWolfsburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2016-12-20 | Boreham WoodvBraintree TownNational League · England | 0–1 | National League · England |
| 2016-12-20 | MechelenvCharleroiPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-12-20 | DortmundvAugsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-12-20 | HamburgvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2016-12-20 | Waasland-BeverenvSt TruidenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2016-12-19 | Viitorul ConstantavFC BotosaniSuperliga · Romania | 3–1 | Superliga · Romania |
| 2016-12-19 | Gaz Metan MediasvAstraSuperliga · Romania | 0–1 | Superliga · Romania |
| 2016-12-19 | FenerbahcevGenclerbirligiSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2016-12-19 | PortovChavesPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2016-12-19 | NurnbergvKaiserslautern2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2016-12-19 | AEKvGianninaSuper League · Greece | 1–1 | Super League · Greece |
| 2016-12-19 | MaritimovFeirensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2016-12-19 | VeronavVirtus EntellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2016-12-19 | BursasporvAntalyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-12-19 | ZaglebievPiast GliwiceEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2016-12-19 | Ath BilbaovCeltaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-12-19 | ReimsvTroyesLigue 2 · France | 2–0 | Ligue 2 · France |
| 2016-12-19 | EvertonvLiverpoolPremier League · England | 0–1 | Premier League · England |