| 2022-02-12 | Port ValevNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2022-02-08 | NorthamptonvNewport CountyLeague Two · England | 1–0 | League Two · England |
| 2022-02-05 | WalsallvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2022-02-01 | NorthamptonvBarrowLeague Two · England | 0–1 | League Two · England |
| 2022-01-29 | NorthamptonvSalfordLeague Two · England | 1–0 | League Two · England |
| 2022-01-22 | SuttonvNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2022-01-15 | NorthamptonvForest GreenLeague Two · England | 1–1 | League Two · England |
| 2022-01-08 | NorthamptonvCrawley TownLeague Two · England | 0–1 | League Two · England |
| 2022-01-01 | SwindonvNorthamptonLeague Two · England | 5–2 | League Two · England |
| 2021-12-11 | HarrogatevNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-12-07 | ExetervNorthamptonLeague Two · England | 1–2 | League Two · England |
| 2021-11-27 | NorthamptonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-11-23 | NorthamptonvOldhamLeague Two · England | 2–1 | League Two · England |
| 2021-11-20 | BradfordvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2021-11-13 | Bristol RvsvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2021-10-30 | NorthamptonvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-23 | TranmerevNorthamptonLeague Two · England | 0–2 | League Two · England |
| 2021-10-19 | NorthamptonvStevenageLeague Two · England | 3–0 | League Two · England |
| 2021-10-16 | NorthamptonvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2021-10-09 | HartlepoolvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2021-10-02 | NorthamptonvSuttonLeague Two · England | 0–2 | League Two · England |
| 2021-09-25 | SalfordvNorthamptonLeague Two · England | 2–2 | League Two · England |
| 2021-09-18 | NorthamptonvSwindonLeague Two · England | 1–1 | League Two · England |
| 2021-09-14 | Newport CountyvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-09-11 | Forest GreenvNorthamptonLeague Two · England | 1–0 | League Two · England |
| 2021-09-04 | NorthamptonvScunthorpeLeague Two · England | 2–0 | League Two · England |
| 2021-08-28 | Crawley TownvNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2021-08-21 | NorthamptonvRochdaleLeague Two · England | 1–3 | League Two · England |
| 2021-08-14 | ColchestervNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2021-08-07 | NorthamptonvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2021-05-09 | SunderlandvNorthamptonLeague One · England | 1–1 | League One · England |
| 2021-05-01 | NorthamptonvBlackpoolLeague One · England | 0–3 | League One · England |
| 2021-04-24 | GillinghamvNorthamptonLeague One · England | 2–2 | League One · England |
| 2021-04-20 | NorthamptonvIpswichLeague One · England | 3–0 | League One · England |
| 2021-04-16 | PeterborovNorthamptonLeague One · England | 3–1 | League One · England |
| 2021-04-10 | NorthamptonvBristol RvsLeague One · England | 1–1 | League One · England |
| 2021-04-05 | HullvNorthamptonLeague One · England | 3–0 | League One · England |
| 2021-04-02 | NorthamptonvShrewsburyLeague One · England | 1–0 | League One · England |
| 2021-03-27 | AFC WimbledonvNorthamptonLeague One · England | 1–0 | League One · England |
| 2021-03-23 | NorthamptonvOxfordLeague One · England | 1–0 | League One · England |
| 2021-03-20 | NorthamptonvCreweLeague One · England | 0–1 | League One · England |
| 2021-03-13 | DoncastervNorthamptonLeague One · England | 0–0 | League One · England |
| 2021-03-09 | CharltonvNorthamptonLeague One · England | 2–1 | League One · England |
| 2021-03-06 | NorthamptonvPortsmouthLeague One · England | 4–1 | League One · England |
| 2021-03-02 | NorthamptonvPlymouthLeague One · England | 2–0 | League One · England |
| 2021-02-27 | SwindonvNorthamptonLeague One · England | 2–1 | League One · England |
| 2021-02-23 | NorthamptonvRochdaleLeague One · England | 0–0 | League One · England |
| 2021-02-20 | Milton Keynes DonsvNorthamptonLeague One · England | 4–3 | League One · England |
| 2021-02-16 | IpswichvNorthamptonLeague One · England | 0–0 | League One · England |
| 2021-02-13 | NorthamptonvBurtonLeague One · England | 0–2 | League One · England |