| 2021-10-31 | Brestv MonacoLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-31 | FamalicaovVizelaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-10-31 | Cercle BruggevAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-10-31 | Minnesota UnitedvSporting Kansas CityMLS · United States | 2–1 | MLS · United States |
| 2021-10-31 | Sparta RotterdamvFeyenoordEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-10-31 | Sport RecifevAtletico GOSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-10-31 | TroyesvRennesLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-10-31 | ZaragozavMirandesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-31 | HakavMariehamnVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-10-31 | FuenlabradavGironaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-31 | DC UnitedvColumbus CrewMLS · United States | 1–3 | MLS · United States |
| 2021-10-31 | VikingvSarpsborg 08Eliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-10-31 | WaalwijkvCambuurEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-10-31 | AC OuluvKTPVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-10-31 | Houston DynamovColorado RapidsMLS · United States | 0–1 | MLS · United States |
| 2021-10-31 | Aston VillavWest HamPremier League · England | 1–4 | Premier League · England |
| 2021-10-31 | GremiovPalmeirasSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2021-10-31 | Randers FCvMidtjyllandSuperliga · Denmark | 1–3 | Superliga · Denmark |
| 2021-10-31 | NorrkopingvElfsborgAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2021-10-31 | KhimkivUralPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-10-31 | FCSBvFC ArgesSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-10-31 | GianninavAsteras TripolisSuper League · Greece | 1–1 | Super League · Greece |
| 2021-10-31 | Union de Santa FevRosario CentralLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-10-31 | Estudiantes L.P.vRiver PlateLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-10-31 | SassuolovEmpoliSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-10-31 | StromsgodsetvMoldeEliteserien · Norway | 6–0 | Eliteserien · Norway |
| 2021-10-31 | SionvGrasshoppersSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-10-31 | PanathinaikosvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2021-10-31 | HIFKvIlvesVeikkausliiga · Finland | 0–3 | Veikkausliiga · Finland |
| 2021-10-31 | Tigres UANLvGuadalajara ChivasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-31 | FC DallasvAustin FCMLS · United States | 2–1 | MLS · United States |
| 2021-10-31 | GentvSt. GilloisePro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-10-31 | AnderlechtvOud-Heverlee LeuvenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-10-31 | Sturm GrazvWolfsberger ACBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2021-10-31 | ViborgvBrondbySuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-10-31 | LausannevLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-10-31 | Newells Old BoysvIndependienteLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-31 | ValerengavBrannEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-10-31 | M'gladbachvBochumBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-10-31 | GetafevEspanolLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-10-31 | Wisla PlockvWislaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-10-31 | NordsjaellandvAalborgSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2021-10-31 | ClermontvMarseilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-10-31 | SK RapidvLASKBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-10-31 | ValladolidvEibarLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-10-30 | NorthamptonvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-30 | Beerschot VAvSeraingPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-10-30 | NecaxavMazatlan FCLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-30 | Talleres CordobavHuracanLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-30 | Pari NNvLokomotiv MoscowPremier League · Russia | 1–2 | Premier League · Russia |