| 2010-10-02 | AlbinoleffevPescaraSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-10-02 | ExcelsiorvRodaEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2010-10-02 | CambridgevBath CityNational League · England | 1–2 | National League · England |
| 2010-10-02 | DumbartonvAirdrie UtdLeague One · Scotland | 1–3 | League One · Scotland |
| 2010-10-02 | MacclesfieldvNorthamptonLeague Two · England | 2–0 | League Two · England |
| 2010-10-02 | ParmavMilanSerie A · Italy | 0–1 | Serie A · Italy |
| 2010-10-02 | AnkaragucuvKonyasporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2010-10-02 | ValenciavAth BilbaoLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-10-02 | FalkirkvCowdenbeathChampionship · Scotland | 5–1 | Championship · Scotland |
| 2010-10-02 | SienavModenaSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-10-02 | NurnbergvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-10-02 | LokerenvGerminalPro League · Belgium | 1–0 | Pro League · Belgium |
| 2010-10-02 | St JohnstonevHibernianPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2010-10-02 | Ross CountyvPartickChampionship · Scotland | 0–2 | Championship · Scotland |
| 2010-10-02 | SassuolovAtalantaSerie B · Italy | 0–2 | Serie B · Italy |
| 2010-10-02 | BarnsleyvCardiffChampionship · England | 1–2 | Championship · England |
| 2010-10-02 | Crystal PalacevQPRChampionship · England | 1–2 | Championship · England |
| 2010-10-02 | TriestinavCrotoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-10-02 | GrimsbyvNewport CountyNational League · England | 2–0 | National League · England |
| 2010-10-02 | BarnetvHerefordLeague Two · England | 2–0 | League Two · England |
| 2010-10-02 | LeicestervScunthorpeChampionship · England | 3–1 | Championship · England |
| 2010-10-02 | ManisasporvKayserisporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-10-02 | SunderlandvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2010-10-02 | OldhamvLeyton OrientLeague One · England | 1–1 | League One · England |
| 2010-10-02 | AccringtonvGillinghamLeague Two · England | 7–4 | League Two · England |
| 2010-10-02 | GimnasticvXerezLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2010-10-02 | Bristol CityvNorwichChampionship · England | 0–3 | Championship · England |
| 2010-10-02 | CarlislevPeterboroLeague One · England | 0–1 | League One · England |
| 2010-10-02 | West HamvFulhamPremier League · England | 1–1 | Premier League · England |
| 2010-10-02 | BrechinvPeterheadLeague One · Scotland | 4–2 | League One · Scotland |
| 2010-10-02 | WalsallvYeovilLeague One · England | 0–1 | League One · England |
| 2010-10-02 | OlympiakosvOlympiakos VolouSuper League · Greece | 3–1 | Super League · Greece |
| 2010-10-02 | ChesterfieldvCreweLeague Two · England | 5–5 | League Two · England |
| 2010-10-02 | SouthendvLincolnLeague Two · England | 1–0 | League Two · England |
| 2010-10-02 | OsnabruckvFortuna Dusseldorf2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2010-10-02 | Fleetwood TownvHistonNational League · England | 1–1 | National League · England |
| 2010-10-02 | WaregemvCharleroiPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-10-02 | BurtonvStockportLeague Two · England | 2–1 | League Two · England |
| 2010-10-02 | Dag and RedvSwindonLeague One · England | 2–1 | League One · England |
| 2010-10-02 | PlymouthvHartlepoolLeague One · England | 0–1 | League One · England |
| 2010-10-02 | BarrowvLutonNational League · England | 0–1 | National League · England |
| 2010-10-02 |  MonacovBrestLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-10-02 | NAC BredavNijmegenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-10-02 | FenerbahcevGenclerbirligiSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2010-10-02 | NancyvLyonLigue 1 · France | 2–3 | Ligue 1 · France |
| 2010-10-02 | Asteras TripolisvAtromitosSuper League · Greece | 1–1 | Super League · Greece |
| 2010-10-02 |  Réunionv MartiniqueCoupe de l'Outre-Mer | 0–0 p | Coupe de l'Outre-Mer |
| 2010-10-02 | SochauxvLensLigue 1 · France | 3–0 | Ligue 1 · France |
| 2010-10-02 | HuescavCeltaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-10-02 | ClydevElginLeague Two · Scotland | 1–1 | League Two · Scotland |