| 2021-10-31 | MontpelliervNantesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-31 | LuganovServetteSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-10-31 | LamiavAtromitosSuper League · Greece | 2–2 | Super League · Greece |
| 2021-10-31 | Sepsi Sf. GheorghevDin. BucurestiSuperliga · Romania | 4–1 | Superliga · Romania |
| 2021-10-31 | IngolstadtvRegensburg2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2021-10-31 | IntervUdineseSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-10-31 | AEKvArisSuper League · Greece | 2–1 | Super League · Greece |
| 2021-10-31 | MotherwellvRangersPremiership · Scotland | 1–6 | Premiership · Scotland |
| 2021-10-31 | MaritimovGil VicentePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-10-31 | Go Ahead EaglesvFor SittardEredivisie · Netherlands | 4–3 | Eredivisie · Netherlands |
| 2021-10-31 | AlanyasporvGoztepSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-10-31 | GenoavVeneziaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-10-31 | CadizvMallorcaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-31 | StrasbourgvLorientLigue 1 · France | 4–0 | Ligue 1 · France |
| 2021-10-31 | Hansa RostockvFortuna Dusseldorf2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-10-31 | NijmegenvGroningenEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-10-31 | Boca JuniorsvGimnasia L.P.Liga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-31 | Sao PaulovInternacionalSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-31 | BordeauxvReimsLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-10-31 | Cruz AzulvClub AmericaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-31 | OddvMjondalenEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-10-31 | Bodo/GlimtvSandefjordEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-10-31 | LahtivHonkaVeikkausliiga · Finland | 2–3 | Veikkausliiga · Finland |
| 2021-10-31 | KuPSvHJKVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-10-31 | AngersvNiceLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-10-31 | SalernitanavNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-10-31 | Ath MadridvBetisLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-10-31 | StabaekvHaugesundEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-31 | Gaz Metan MediasvAcademica ClinceniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-10-31 | OviedovMalagaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-31 | GalatasarayvGaziantepSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-10-31 | KarlsruhevPaderborn2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2021-10-31 | FiorentinavSpeziaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-10-31 | KayserisporvKaragumrukSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-31 | TolucavClub LeonLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-10-31 | Philadelphia UnionvFC CincinnatiMLS · United States | 2–0 | MLS · United States |
| 2021-10-31 | TirolvAustria ViennaBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-10-31 | RomavMilanSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-10-31 | OrebrovDjurgardenAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-10-31 | SonderjyskevSilkeborgSuperliga · Denmark | 0–6 | Superliga · Denmark |
| 2021-10-31 | SociedadvAth BilbaoLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-31 | WaregemvGenkPro League · Belgium | 2–6 | Pro League · Belgium |
| 2021-10-31 | UfavAkhmat GroznyPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-10-31 | Inter TurkuvSJKVeikkausliiga · Finland | 2–5 | Veikkausliiga · Finland |
| 2021-10-31 | UtrechtvWillem IIEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2021-10-31 | FC CopenhagenvVejleSuperliga · Denmark | 3–0 | Superliga · Denmark |
| 2021-10-31 | NorwichvLeedsPremier League · England | 1–2 | Premier League · England |
| 2021-10-31 | BelenensesvSanta ClaraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-10-31 | PachucavUNAM PumasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-31 | Arsenal TulavSochiPremier League · Russia | 1–2 | Premier League · Russia |