| 2021-11-04 | Austin FCvSporting Kansas CityMLS · United States | 3–1 | MLS · United States |
| 2021-11-04 | IbizavTenerifeLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-11-04 | Cruz AzulvClub LeonLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-11-04 | BurgosvZaragozaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-11-04 | DroghedavDundalkPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-11-04 | Real Salt LakevPortland TimbersMLS · United States | 1–3 | MLS · United States |
| 2021-11-04 | PachucavAtl. San LuisLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-11-04 | MalagavSociedad BLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-11-04 | Farul ConstantavFCSBSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-11-04 | GironavAlcorconLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-11-03 | RovaniemivAC OuluVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-11-03 | Sanfrecce HiroshimavKashima AntlersJ1 League · Japan | 1–4 | J1 League · Japan |
| 2021-11-03 | MirandesvLugoLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2021-11-03 | FC TokyovShimizu S-PulseJ1 League · Japan | 4–0 | J1 League · Japan |
| 2021-11-03 | BlackburnvFulhamChampionship · England | 0–7 | Championship · England |
| 2021-11-03 | Treaty UnitedvUC DublinPremier Division · Ireland | 0–3 | Premier Division · Ireland |
| 2021-11-03 | Yokohama FCvSagan TosuJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-11-03 | TokushimavCerezo OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-11-03 | Yokohama F. MarinosvGamba OsakaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-11-03 | Nagoya GrampusvKashiwa ReysolJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-11-03 | Los Angeles FCvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-11-03 | Las PalmasvFuenlabradaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-11-03 | CardiffvQPRChampionship · England | 0–1 | Championship · England |
| 2021-11-03 | West BromvHullChampionship · England | 1–0 | Championship · England |
| 2021-11-03 | CF MontrealvHouston DynamoMLS · United States | 2–0 | MLS · United States |
| 2021-11-03 | BournemouthvPrestonChampionship · England | 1–2 | Championship · England |
| 2021-11-03 | EibarvOviedoLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-11-03 | Vissel KobevVegalta SendaiJ1 League · Japan | 4–2 | J1 League · Japan |
| 2021-11-03 | Kawasaki FrontalevUrawa RedsJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-11-03 | BarnsleyvDerbyChampionship · England | 2–1 | Championship · England |
| 2021-11-03 | Hokkaido Consadole SapporovShonan BellmareJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-11-03 | New York Red BullsvAtlanta UtdMLS · United States | 0–0 | MLS · United States |
| 2021-11-03 | Avispa FukuokavOita TrinitaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-11-03 | BrayvGalwayPremier Division · Ireland | 0–0 | Premier Division · Ireland |
| 2021-11-03 | BlackpoolvStokeChampionship · England | 0–1 | Championship · England |
| 2021-11-03 | AmorebietavValladolidLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2021-11-02 | Sheffield WedsvSunderlandLeague One · England | 3–0 | League One · England |
| 2021-11-02 | Fleetwood TownvWiganLeague One · England | 2–3 | League One · England |
| 2021-11-02 | Athletico-PRvFlamengo RJSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2021-11-02 | Nott'm ForestvSheffield UnitedChampionship · England | 1–1 | Championship · England |
| 2021-11-02 | CorinthiansvChapecoense-SCSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-11-02 | PortsmouthvCheltenhamLeague One · England | 1–1 | League One · England |
| 2021-11-02 | MorecambevCambridgeLeague One · England | 0–2 | League One · England |
| 2021-11-02 | BirminghamvBristol CityChampionship · England | 3–0 | Championship · England |
| 2021-11-02 | Seattle SoundersvLos Angeles GalaxyMLS · United States | 1–1 | MLS · United States |
| 2021-11-02 | WaterfordvDerry CityPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2021-11-02 | CharltonvRotherhamLeague One · England | 1–1 | League One · England |
| 2021-11-02 | Central CordobavAldosiviLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-11-02 | Sp GijonvAlmeriaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-11-02 | LeganesvCartagenaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |