| 2021-11-06 | IndependientevArsenal SarandiLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-11-06 | Man UnitedvMan CityPremier League · England | 0–2 | Premier League · England |
| 2021-11-06 | HeartsvDundee UnitedPremiership · Scotland | 5–2 | Premiership · Scotland |
| 2021-11-06 | BordeauxvParis SGLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-11-06 | NiortvNancyLigue 2 · France | 1–3 | Ligue 2 · France |
| 2021-11-06 | NijmegenvHeerenveenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-11-06 | EspanolvGranadaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-11-06 | PaderbornvIngolstadt2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-11-06 | LuzernvSionSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-11-06 | DjurgardenvHalmstadAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-11-06 | SpeziavTorinoSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-11-06 | LugovPonferradinaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-11-06 | WolfsburgvAugsburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-11-06 | PueblavTolucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-11-06 | Arsenal TulavUfaPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-11-06 | Krylya SovetovvKhimkiPremier League · Russia | 3–0 | Premier League · Russia |
| 2021-11-06 | CagliarivAtalantaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-11-06 | OFI CretevAtromitosSuper League · Greece | 2–0 | Super League · Greece |
| 2021-11-06 | Sarpsborg 08vStabaekEliteserien · Norway | 4–1 | Eliteserien · Norway |
| 2021-11-06 | Colon Santa FEvPlatenseLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-11-06 | GianninavPanetolikosSuper League · Greece | 3–0 | Super League · Greece |
| 2021-11-06 | CardiffvHuddersfieldChampionship · England | 2–1 | Championship · England |
| 2021-11-06 | GrenoblevDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-11-06 | Shimizu S-PulsevHokkaido Consadole SapporoJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-11-06 | ZwollevCambuurEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-11-06 | Dynamo MoscowvKrasnodarPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-11-06 | ForfarvElginLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2021-11-06 | Airdrie UtdvPeterheadLeague One · Scotland | 3–1 | League One · Scotland |
| 2021-11-06 | AscolivVicenzaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-11-06 | KilmarnockvPartickChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-11-06 | AlessandriavTernanaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-11-06 | Atl. TucumanvRacing ClubLiga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2021-11-06 | Annan AthleticvStranraerLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2021-11-06 | SochauxvNimesLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-11-06 | FuenlabradavEibarLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-11-06 | RegensburgvHansa Rostock2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-11-06 | ChelseavBurnleyPremier League · England | 1–1 | Premier League · England |
| 2021-11-06 | St JohnstonevSt MirrenPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-11-06 | SochivCSKA MoscowPremier League · Russia | 4–1 | Premier League · Russia |
| 2021-11-06 | StirlingvStenhousemuirLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2021-11-06 | MjallbyvSiriusAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-11-06 | BesiktasvTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-11-06 | BeneventovFrosinoneSerie B · Italy | 1–4 | Serie B · Italy |
| 2021-11-06 | Austria ViennavSalzburgBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-11-06 | BarnsleyvHullChampionship · England | 0–2 | Championship · England |
| 2021-11-06 | AntalyasporvAltaySüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-11-06 | CowdenbeathvKelty HeartsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-11-06 | PeterborovFulhamChampionship · England | 0–1 | Championship · England |
| 2021-11-06 | CeltavBarcelonaLa Liga · Spain | 3–3 | La Liga · Spain |
| 2021-11-06 | BrightonvNewcastlePremier League · England | 1–1 | Premier League · England |