| 2008-10-19 | OlympiakosvPanthrakikosSuper League · Greece | 2–0 | Super League · Greece |
| 2008-10-19 | GenoavSienaSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-10-19 | GraafschapvAZ AlkmaarEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2008-10-19 | Sp GijonvOsasunaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2008-10-19 | Club BruggevCercle BruggePro League · Belgium | 3–1 | Pro League · Belgium |
| 2008-10-19 | RomavInterSerie A · Italy | 0–4 | Serie A · Italy |
| 2008-10-19 | Ath BilbaovBarcelonaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2008-10-19 | CataniavPalermoSerie A · Italy | 2–0 | Serie A · Italy |
| 2008-10-19 | BolognavLazioSerie A · Italy | 3–1 | Serie A · Italy |
| 2008-10-19 | Sheffield WedsvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2008-10-19 | ValenciavNumanciaLa Liga · Spain | 4–0 | La Liga · Spain |
| 2008-10-19 | Le MansvNancyLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-10-19 | Willem IIvFeyenoordEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2008-10-19 | LevadeiakosvXanthiSuper League · Greece | 0–0 | Super League · Greece |
| 2008-10-19 | Munich 1860vGreuther Furth2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2008-10-19 | ValenciennesvMarseilleLigue 1 · France | 1–3 | Ligue 1 · France |
| 2008-10-19 | NijmegenvVitesseEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2008-10-19 | DuisburgvIngolstadt2. Bundesliga · Germany | 6–1 | 2. Bundesliga · Germany |
| 2008-10-19 | MilanvSampdoriaSerie A · Italy | 3–0 | Serie A · Italy |
| 2008-10-19 |  Bruneiv PhilippinesAFF Championship qualification | 1–1 | AFF Championship qualification |
| 2008-10-19 | HerculesvElcheLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2008-10-19 | BetisvMallorcaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2008-10-19 | GimnasticvVallecanoLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2008-10-19 | SpartavUtrechtEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2008-10-19 | GenclerbirligivBesiktasSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2008-10-19 | WaregemvAnderlechtPro League · Belgium | 4–0 | Pro League · Belgium |
| 2008-10-19 | ChievovAtalantaSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-10-19 | StokevTottenhamPremier League · England | 2–1 | Premier League · England |
| 2008-10-19 | SantandervLa CorunaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2008-10-19 | AuxerrevRennesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2008-10-19 | SivassporvAnkaragucuSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2008-10-19 | AugsburgvSt Pauli2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2008-10-19 | LeccevUdineseSerie A · Italy | 2–2 | Serie A · Italy |
| 2008-10-19 | TorinovCagliariSerie A · Italy | 0–1 | Serie A · Italy |
| 2008-10-19 | HullvWest HamPremier League · England | 1–0 | Premier League · England |
| 2008-10-19 | AlmeriavSevillaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2008-10-19 | ChestervPort ValeLeague Two · England | 1–2 | League Two · England |
| 2008-10-19 | AEKvLarisaSuper League · Greece | 1–1 | Super League · Greece |
| 2008-10-19 | KayserisporvAnkarasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2008-10-19 | OFIvThrasyvoulosSuper League · Greece | 1–3 | Super League · Greece |
| 2008-10-18 | BrightonvHerefordLeague One · England | 0–0 | League One · England |
| 2008-10-18 | GerminalvCharleroiPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-10-18 | LutonvAccringtonLeague Two · England | 1–2 | League Two · England |
| 2008-10-18 | MontrosevDumbartonLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2008-10-18 | MortonvClydeChampionship · Scotland | 1–0 | Championship · Scotland |
| 2008-10-18 | CrewevMilton Keynes DonsLeague One · England | 2–2 | League One · England |
| 2008-10-18 | Airdrie UtdvQueen of SthChampionship · Scotland | 2–0 | Championship · Scotland |
| 2008-10-18 | HamiltonvSt MirrenPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2008-10-18 | Roda JCvHeerenveenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2008-10-18 | YorkvRushden & DNational League · England | 2–0 | National League · England |