| 2021-11-06 | FalkirkvAlloaLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-11-06 | MontrosevCove RangersLeague One · Scotland | 0–0 | League One · Scotland |
| 2021-11-06 | EupenvWaregemPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-11-06 | Le HavrevValenciennesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-11-06 | VizelavEstorilPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-11-06 | LecznavLech PoznanEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-11-06 | LutonvStokeChampionship · England | 0–1 | Championship · England |
| 2021-11-06 | ApollonvAEKSuper League · Greece | 2–2 | Super League · Greece |
| 2021-11-06 | Piast GliwicevWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-11-06 | DumbartonvClydeLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-11-06 | StuttgartvBielefeldBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-11-06 | AmiensvCaenLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-11-06 | ComovPerugiaSerie B · Italy | 4–1 | Serie B · Italy |
| 2021-11-06 | Nott'm ForestvPrestonChampionship · England | 3–0 | Championship · England |
| 2021-11-06 | Queen of SthvRaith RvsChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-11-06 | RB LeipzigvDortmundBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-11-06 | SivassporvGiresunsporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-11-06 | MechelenvSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-11-06 | AyrvInverness CChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-11-06 | ValladolidvMirandesLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-11-06 | Paris FCvRodezLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-11-06 | Queens ParkvEast FifeLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-11-06 | Club LeonvNecaxaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-11-06 | Quevilly RouenvToulouseLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-11-06 | Yokohama F. MarinosvFC TokyoJ1 League · Japan | 8–0 | J1 League · Japan |
| 2021-11-06 | Lechia GdanskvZaglebieEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-11-06 | DunfermlinevMortonChampionship · Scotland | 1–3 | Championship · Scotland |
| 2021-11-06 | PortimonensevBelenensesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-11-06 | St. GilloisevCharleroiPro League · Belgium | 4–0 | Pro League · Belgium |
| 2021-11-06 | AjacciovDijonLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-11-06 | BrentfordvNorwichPremier League · England | 1–2 | Premier League · England |
| 2021-11-06 | Mazatlan FCvGuadalajara ChivasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-11-06 | BlackpoolvQPRChampionship · England | 1–1 | Championship · England |
| 2021-11-06 | MillwallvDerbyChampionship · England | 1–1 | Championship · England |
| 2021-11-06 | BirminghamvReadingChampionship · England | 1–2 | Championship · England |
| 2021-11-06 | Real MadridvVallecanoLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-11-06 | HartbergvA. KlagenfurtBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-11-06 | LanusvEstudiantes L.P.Liga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-11-06 | BochumvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-11-06 | HamiltonvArbroathChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-11-06 | BlackburnvSheffield UnitedChampionship · England | 3–1 | Championship · England |
| 2021-11-06 | OviedovLas PalmasLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-11-06 | CorinthiansvFortalezaSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-11-06 | InternacionalvGremioSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-11-06 | AuxerrevPau FCLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-11-06 | MiovenivUTA AradSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-11-06 | Radomiak RadomvGornik Z.Ekstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-11-06 | GuingampvBastiaLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-11-06 | CoventryvBristol CityChampionship · England | 3–2 | Championship · England |
| 2021-11-06 | U Craiova 1948vSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |