| 2021-11-07 | OlympiakosvIonikosSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2021-11-07 | UC DublinvTreaty UnitedLeague of Ireland Premier Division · Republic of Ireland | 1–2 | League of Ireland Premier Division · Republic of Ireland |
| 2021-11-07 | Columbus CrewvChicago FireMLS · United States | 2–0 | MLS · United States |
| 2021-11-07 | Los Angeles GalaxyvMinnesota UnitedMLS · United States | 3–3 | MLS · United States |
| 2021-11-07 | WislavCracoviaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-11-07 | For SittardvPSV EindhovenEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-11-07 | SampdoriavBolognaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-11-07 | ArsenalvWatfordPremier League · England | 1–0 | Premier League · England |
| 2021-11-07 | GroningenvWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-11-07 | Club TijuanavPachucaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2021-11-07 | LASKvTirolAustrian Bundesliga · Austria | 3–0 | Austrian Bundesliga · Austria |
| 2021-11-07 | HackenvDegerforsAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-11-07 | GoteborgvMalmo FFAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-11-07 | Oita TrinitavGamba OsakaJ1 League · Japan | 2–3 | J1 League · Japan |
| 2021-11-07 | DundalkvLongfordLeague of Ireland Premier Division · Republic of Ireland | 2–0 | League of Ireland Premier Division · Republic of Ireland |
| 2021-11-07 | MarseillevMetzLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-11-07 | GoztepvKonyasporSüper Lig · Türkiye | 0–2 | Süper Lig · Türkiye |
| 2021-11-07 | NapolivVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-11-07 | OsasunavSociedadLaLiga · Spain | 0–2 | LaLiga · Spain |
| 2021-11-07 | St EtiennevClermontLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-11-07 | OddvKristiansundEliteserien · Norway | 2–4 | Eliteserien · Norway |
| 2021-11-07 | BaselvSt. GallenSwiss Super League · Switzerland | 0–1 | Swiss Super League · Switzerland |
| 2021-11-07 | KaragumrukvGalatasaraySüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2021-11-07 | CittadellavPisaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-11-07 | San Jose EarthquakesvFC DallasMLS · United States | 1–1 | MLS · United States |
| 2021-11-07 | SeraingvGentPro League · Belgium | 0–0 | Pro League · Belgium |
| 2021-11-07 | Reimsv MonacoLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-11-07 | Kashima AntlersvUrawa RedsJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-11-07 | PanathinaikosvPAOKSuper League Greece · Greece | 1–3 | Super League Greece · Greece |
| 2021-11-07 | MilanvInterSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-11-07 | NicevMontpellierLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-11-07 | Farul ConstantavUniv. CraiovaLiga I · Romania | 1–0 | Liga I · Romania |
| 2021-11-07 | CearavCuiabaBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-07 | Din. BucurestivCFR ClujLiga I · Romania | 0–3 | Liga I · Romania |
| 2021-11-07 | Sagan TosuvKawasaki FrontaleJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-11-07 | Gimnasia L.P.vBanfieldLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-11-07 | Volos NFCvArisSuper League Greece · Greece | 1–2 | Super League Greece · Greece |
| 2021-11-07 | MoldevSandefjordEliteserien · Norway | 3–1 | Eliteserien · Norway |
| 2021-11-07 | GenkvCercle BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-11-07 | HammarbyvOrebroAllsvenskan · Sweden | 3–2 | Allsvenskan · Sweden |
| 2021-11-07 | CrotonevMonzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-07 | BrondbyvOdenseDanish Superliga · Denmark | 2–1 | Danish Superliga · Denmark |
| 2021-11-07 | NantesvStrasbourgLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-11-07 | FC VoluntarivFCSBLiga I · Romania | 0–0 | Liga I · Romania |
| 2021-11-07 | Sporting Kansas CityvReal Salt LakeMLS · United States | 0–1 | MLS · United States |
| 2021-11-07 | HaugesundvBodo/GlimtEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-11-07 | LeccevParmaSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-11-06 | Crystal PalacevWolvesPremier League · England | 2–0 | Premier League · England |
| 2021-11-06 | ElfsborgvVarbergAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-11-06 | Godoy CruzvTalleres CordobaLiga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |