| 2010-10-16 | HuddersfieldvSouthamptonLeague One · England | 2–0 | League One · England |
| 2010-10-16 | PortogruarovVareseSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-10-16 | LivingstonvStenhousemuirLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-10-16 | ScunthorpevDoncasterChampionship · England | 1–3 | Championship · England |
| 2010-10-16 | EupenvSt TruidenPro League · Belgium | 6–0 | Pro League · Belgium |
| 2010-10-16 | Crawley TownvNewport CountyNational League · England | 2–3 | National League · England |
| 2010-10-16 | TriestinavRegginaSerie B · Italy | 0–4 | Serie B · Italy |
| 2010-10-16 | LeicestervHullChampionship · England | 1–1 | Championship · England |
| 2010-10-16 | RomavGenoaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-10-16 | AlcorconvXerezLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-10-16 | East StirlingvStranraerLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2010-10-16 | BesiktasvManisasporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2010-10-16 | XanthivOlympiakosSuper League · Greece | 0–3 | Super League · Greece |
| 2010-10-16 | Kettering TownvKidderminsterNational League · England | 1–1 | National League · England |
| 2010-10-16 | FulhamvTottenhamPremier League · England | 1–2 | Premier League · England |
| 2010-10-16 | GimnasticvBarcelona BLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-10-16 | MalagavReal MadridLa Liga · Spain | 1–4 | La Liga · Spain |
| 2010-10-16 | CardiffvBristol CityChampionship · England | 3–2 | Championship · England |
| 2010-10-16 | BrestvArlesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-10-16 | PartickvFalkirkChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-10-16 | NorthamptonvHerefordLeague Two · England | 3–4 | League Two · England |
| 2010-10-16 | CambridgevBarrowNational League · England | 3–1 | National League · England |
| 2010-10-16 | BournemouthvMilton Keynes DonsLeague One · England | 3–2 | League One · England |
| 2010-10-16 | GaziantepsporvBucasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2010-10-16 | MontrosevBerwickLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2010-10-16 | PeterheadvDumbartonLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-10-16 | OldhamvColchesterLeague One · England | 0–0 | League One · England |
| 2010-10-16 | GentvKortrijkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2010-10-16 | PortsmouthvWatfordChampionship · England | 3–2 | Championship · England |
| 2010-10-16 | YeovilvSheffield WedsLeague One · England | 0–2 | League One · England |
| 2010-10-16 | CowdenbeathvRaith RvsChampionship · Scotland | 1–2 | Championship · Scotland |
| 2010-10-16 | IpswichvCoventryChampionship · England | 1–2 | Championship · England |
| 2010-10-16 | FeyenoordvTwenteEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2010-10-16 | AtalantavAscoliSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-10-16 | WolfsburgvLeverkusenBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2010-10-16 | SouthendvCreweLeague Two · England | 0–2 | League Two · England |
| 2010-10-16 | AlbacetevPonferradinaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2010-10-16 | TorquayvBuryLeague Two · England | 3–4 | League Two · England |
| 2010-10-16 | TranmerevBrentfordLeague One · England | 0–3 | League One · England |
| 2010-10-15 | Union BerlinvErzgebirge Aue2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-10-15 | IstresvNimesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-10-15 |  Curaçaov GuyanaCFU Caribbean Cup qualification | 2–3 | CFU Caribbean Cup qualification |
| 2010-10-15 |  Surinamev Saint LuciaCFU Caribbean Cup qualification | 2–1 | CFU Caribbean Cup qualification |
| 2010-10-15 | FC KolnvDortmundBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-10-15 | VannesvChateaurouxLigue 2 · France | 0–1 | Ligue 2 · France |
| 2010-10-15 | LavalvGrenobleLigue 2 · France | 3–0 | Ligue 2 · France |
| 2010-10-15 | RecreativovSalamancaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2010-10-15 | NantesvToursLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-10-15 | Evian Thonon GaillardvAngersLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-10-15 | BursasporvKarabuksporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |