| 2021-11-07 | HerthavLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-11-07 | New York CityvPhiladelphia UnionMLS · United States | 1–1 | MLS · United States |
| 2021-11-07 | Avispa FukuokavYokohama FCJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-11-07 | Colorado RapidsvLos Angeles FCMLS · United States | 5–2 | MLS · United States |
| 2021-11-07 | BenficavSp BragaPrimeira Liga · Portugal | 6–1 | Primeira Liga · Portugal |
| 2021-11-07 | FC KolnvUnion BerlinBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-11-07 | Akhmat GroznyvPari NNRussian Premier League · Russia | 3–1 | Russian Premier League · Russia |
| 2021-11-07 | VitessevUtrechtEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-11-07 | Sociedad BvIbizaLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2021-11-07 | LausannevLuganoSwiss Super League · Switzerland | 0–2 | Swiss Super League · Switzerland |
| 2021-11-07 | Atletico-MGvAmerica MGBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-07 | UNAM PumasvCruz AzulLiga MX · Mexico | 4–3 | Liga MX · Mexico |
| 2021-11-07 | VejlevSonderjyskeDanish Superliga · Denmark | 3–1 | Danish Superliga · Denmark |
| 2021-11-07 | New England RevolutionvInter MiamiMLS · United States | 0–1 | MLS · United States |
| 2021-11-07 | FC CincinnativAtlanta UtdMLS · United States | 1–2 | MLS · United States |
| 2021-11-07 | BohemiansvDroghedaLeague of Ireland Premier Division · Republic of Ireland | 2–1 | League of Ireland Premier Division · Republic of Ireland |
| 2021-11-07 | Velez SarsfieldvSan LorenzoLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-11-07 | CartagenavMalagaLaLiga 2 · Spain | 3–1 | LaLiga 2 · Spain |
| 2021-11-07 | FluminensevSport RecifeBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-07 | Spartak MoscowvLokomotiv MoscowRussian Premier League · Russia | 1–1 | Russian Premier League · Russia |
| 2021-11-07 | ServettevZurichSwiss Super League · Switzerland | 1–2 | Swiss Super League · Switzerland |
| 2021-11-07 | BahiavSao PauloBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-07 | Shonan BellmarevSanfrecce HiroshimaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-11-07 | TromsovStromsgodsetEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-11-07 | BetisvSevillaLaLiga · Spain | 0–2 | LaLiga · Spain |
| 2021-11-07 | River PlatevPatronatoLiga Profesional · Argentina | 5–0 | Liga Profesional · Argentina |
| 2021-11-07 | AntwerpvAnderlechtPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-11-07 | BragantinovAthletico-PRBrasileirão · Brazil | 0–2 | Brasileirão · Brazil |
| 2021-11-07 | Portland TimbersvAustin FCMLS · United States | 3–0 | MLS · United States |
| 2021-11-07 | Asteras TripolisvLamiaSuper League Greece · Greece | 0–1 | Super League Greece · Greece |
| 2021-11-07 | FeyenoordvAZ AlkmaarEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-11-07 | DundeevCelticPremiership · Scotland | 2–4 | Premiership · Scotland |
| 2021-11-07 | AC OuluvRovaniemiVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-11-07 | Tigres UANLvJuarezLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-11-07 | Schalke 04vDarmstadt2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2021-11-07 | LillestromvValerengaEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-11-07 | RakowvPogon SzczecinEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-11-07 | Sarmiento JuninvCentral CordobaLiga Profesional · Argentina | 1–3 | Liga Profesional · Argentina |
| 2021-11-07 | Vegalta SendaivNagoya GrampusJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-11-07 | Santa ClaravPortoPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-11-07 | LeedsvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2021-11-07 | VeneziavRomaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-11-07 | AlmeriavBurgosLaLiga 2 · Spain | 2–0 | LaLiga 2 · Spain |
| 2021-11-07 | GalwayvBrayLeague of Ireland Premier Division · Republic of Ireland | 0–1 | League of Ireland Premier Division · Republic of Ireland |
| 2021-11-07 | AarhusvMidtjyllandDanish Superliga · Denmark | 3–0 | Danish Superliga · Denmark |
| 2021-11-07 | MjondalenvVikingEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2021-11-07 | West HamvLiverpoolPremier League · England | 3–2 | Premier League · England |
| 2021-11-07 | Vancouver WhitecapsvSeattle SoundersMLS · United States | 1–1 | MLS · United States |
| 2021-11-07 | LegiavStal MielecEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-11-07 | Pacos FerreiravSp LisbonPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |