| 2011-10-22 | Braintree TownvDarlingtonNational League · England | 3–1 | National League · England |
| 2011-10-22 | PartickvFalkirkChampionship · Scotland | 2–2 | Championship · Scotland |
| 2011-10-22 | OldhamvWycombeLeague One · England | 2–0 | League One · England |
| 2011-10-22 | SampdoriavCittadellaSerie B · Italy | 0–0 | Serie B · Italy |
| 2011-10-22 | ReadingvSouthamptonChampionship · England | 1–1 | Championship · England |
| 2011-10-22 | CordobavLa CorunaLaLiga 2 · Spain | 0–2 | LaLiga 2 · Spain |
| 2011-10-22 | SantandervEspanolLaLiga · Spain | 0–1 | LaLiga · Spain |
| 2011-10-22 | MansfieldvAlfreton TownNational League · England | 3–2 | National League · England |
| 2011-10-22 | PeterborovLeedsChampionship · England | 2–3 | Championship · England |
| 2011-10-22 | Den HaagvNijmegenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2011-10-22 | PanathinaikosvErgotelisSuper League Greece · Greece | 4–0 | Super League Greece · Greece |
| 2011-10-22 | GentvLokerenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2011-10-22 | Juve StabiavBariSerie B · Italy | 1–0 | Serie B · Italy |
| 2011-10-22 | GimnasticvHerculesLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2011-10-22 | Aston VillavWest BromPremier League · England | 1–2 | Premier League · England |
| 2011-10-22 | KarabuksporvBuyuksehyrSüper Lig · Türkiye | 2–0 | Süper Lig · Türkiye |
| 2011-10-22 | ChesterfieldvHartlepoolLeague One · England | 2–3 | League One · England |
| 2011-10-22 | GironavCartagenaLaLiga 2 · Spain | 0–2 | LaLiga 2 · Spain |
| 2011-10-22 | Hayes & YeadingvYorkNational League · England | 2–4 | National League · England |
| 2011-10-22 | PortsmouthvDoncasterChampionship · England | 3–1 | Championship · England |
| 2011-10-22 | Milton Keynes DonsvScunthorpeLeague One · England | 0–0 | League One · England |
| 2011-10-22 | JuventusvGenoaSerie A · Italy | 2–2 | Serie A · Italy |
| 2011-10-22 | HoffenheimvM'gladbachBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2011-10-22 | FiorentinavCataniaSerie A · Italy | 2–2 | Serie A · Italy |
| 2011-10-22 | HerefordvBarnetLeague Two · England | 1–0 | League Two · England |
| 2011-10-22 | BournemouthvBuryLeague One · England | 1–2 | League One · England |
| 2011-10-22 | PescaravAscoliSerie B · Italy | 4–1 | Serie B · Italy |
| 2011-10-22 | BradfordvNorthamptonLeague Two · England | 2–1 | League Two · England |
| 2011-10-22 | BordeauxvBrestLigue 1 · France | 1–1 | Ligue 1 · France |
| 2011-10-22 | GenkvBergenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2011-10-22 | East FifevStirlingLeague One · Scotland | 1–0 | League One · Scotland |
| 2011-10-22 | CardiffvBarnsleyChampionship · England | 5–3 | Championship · England |
| 2011-10-22 | VVV VenlovWaalwijkEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2011-10-22 | StevenagevYeovilLeague One · England | 0–0 | League One · England |
| 2011-10-22 | NurnbergvStuttgartBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2011-10-22 | ExcelsiorvHeraclesEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2011-10-22 | Notts CountyvBrentfordLeague One · England | 1–1 | League One · England |
| 2011-10-22 | ModenavLivornoSerie B · Italy | 1–0 | Serie B · Italy |
| 2011-10-22 | BarcelonavSevillaLaLiga · Spain | 0–0 | LaLiga · Spain |
| 2011-10-22 | DortmundvFC KolnBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2011-10-22 | ValladolidvNumanciaLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2011-10-22 | DumbartonvAirdrie UtdLeague One · Scotland | 1–1 | League One · Scotland |
| 2011-10-22 | KaiserslauternvFreiburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2011-10-22 | CharltonvCarlisleLeague One · England | 4–0 | League One · England |
| 2011-10-22 | Raith RvsvQueen of SthChampionship · Scotland | 0–2 | Championship · Scotland |
| 2011-10-22 | RotherhamvShrewsburyLeague Two · England | 1–1 | League Two · England |
| 2011-10-22 | LorientvToulouseLigue 1 · France | 0–0 | Ligue 1 · France |
| 2011-10-22 | MotherwellvKilmarnockPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2011-10-22 | AtromitosvGianninaSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2011-10-22 | Beira MarvBenficaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |