| 2008-10-25 | NorwichvDoncasterChampionship · England | 2–1 | Championship · England |
| 2008-10-25 | ReadingvQPRChampionship · England | 0–0 | Championship · England |
| 2008-10-25 | SalernitanavAnconaSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-10-25 |  Cambodiav BruneiAFF Championship qualification | 2–1 | AFF Championship qualification |
| 2008-10-25 | BelenensesvGuimaraesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2008-10-25 | YeovilvLeyton OrientLeague One · England | 0–0 | League One · England |
| 2008-10-25 | LeicestervNorthamptonLeague One · England | 0–0 | League One · England |
| 2008-10-25 | SwanseavSouthamptonChampionship · England | 3–0 | Championship · England |
| 2008-10-25 | Nott'm ForestvCardiffChampionship · England | 0–1 | Championship · England |
| 2008-10-25 | HerefordvStockportLeague One · England | 0–1 | League One · England |
| 2008-10-25 |  Surinamev Curaçaoplayed as Netherlands AntillesCFU Caribbean Cup qualification | 2–1 | CFU Caribbean Cup qualification |
| 2008-10-25 | PSV EindhovenvRoda JCEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2008-10-25 | Sheffield UnitedvPrestonChampionship · England | 1–0 | Championship · England |
| 2008-10-25 | ChesterfieldvNotts CountyLeague Two · England | 3–1 | League Two · England |
| 2008-10-25 | St JohnstonevPartickChampionship · Scotland | 3–0 | Championship · Scotland |
| 2008-10-25 | BuryvLutonLeague Two · England | 1–2 | League Two · England |
| 2008-10-25 | WesterlovTubizePro League · Belgium | 4–1 | Pro League · Belgium |
| 2008-10-25 | Asteras TripolisvOFISuper League · Greece | 2–2 | Super League · Greece |
| 2008-10-25 |  Cubav BarbadosCFU Caribbean Cup qualification | 1–1 | CFU Caribbean Cup qualification |
| 2008-10-25 | EvertonvMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2008-10-25 | CharleroivLokerenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2008-10-25 | RochdalevAldershotLeague Two · England | 3–1 | League Two · England |
| 2008-10-25 | BrechinvQueens ParkLeague One · Scotland | 2–1 | League One · Scotland |
| 2008-10-25 | VallecanovEibarLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2008-10-25 | Bristol RvsvSouthendLeague One · England | 4–2 | League One · England |
| 2008-10-25 | FenerbahcevBursasporSüper Lig · Turkey | 5–2 | Süper Lig · Turkey |
| 2008-10-25 | BournemouthvLincolnLeague Two · England | 0–1 | League Two · England |
| 2008-10-25 | LarisavPanthrakikosSuper League · Greece | 1–2 | Super League · Greece |
| 2008-10-25 | MantovavParmaSerie B · Italy | 1–3 | Serie B · Italy |
| 2008-10-25 | AuxerrevLyonLigue 1 · France | 0–0 | Ligue 1 · France |
| 2008-10-25 | West BromvHullPremier League · England | 0–3 | Premier League · England |
| 2008-10-25 | Cercle BruggevDenderPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-10-25 | TrevisovPiacenzaSerie B · Italy | 3–2 | Serie B · Italy |
| 2008-10-25 | AlloavPeterheadLeague One · Scotland | 1–0 | League One · Scotland |
| 2008-10-25 | CelticvHibernianPremiership · Scotland | 4–2 | Premiership · Scotland |
| 2008-10-25 | East FifevArbroathLeague One · Scotland | 3–2 | League One · Scotland |
| 2008-10-25 | CharltonvBurnleyChampionship · England | 1–1 | Championship · England |
| 2008-10-25 | BergenvGerminalPro League · Belgium | 0–0 | Pro League · Belgium |
| 2008-10-25 | BlackpoolvCrystal PalaceChampionship · England | 2–2 | Championship · England |
| 2008-10-25 | LeedsvWalsallLeague One · England | 3–0 | League One · England |
| 2008-10-25 | LivornovRiminiSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-10-25 | LillevCaenLigue 1 · France | 2–2 | Ligue 1 · France |
| 2008-10-25 | PlymouthvIpswichChampionship · England | 1–3 | Championship · England |
| 2008-10-25 | BarivGrossetoSerie B · Italy | 3–1 | Serie B · Italy |
| 2008-10-25 | PAOKvLevadeiakosSuper League · Greece | 3–1 | Super League · Greece |
| 2008-10-25 | MacclesfieldvRotherhamLeague Two · England | 1–2 | League Two · England |
| 2008-10-25 | ModenavBresciaSerie B · Italy | 1–3 | Serie B · Italy |
| 2008-10-25 | HannovervWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2008-10-25 | BarnsleyvBristol CityChampionship · England | 0–0 | Championship · England |
| 2008-10-25 | OsasunavBetisLa Liga · Spain | 0–2 | La Liga · Spain |