| 2010-10-17 | Dundee UnitedvCelticPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-10-17 | KaiserslauternvEin FrankfurtBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2010-10-17 | KasimpasavTrabzonsporSüper Lig · Turkey | 0–7 | Süper Lig · Turkey |
| 2010-10-17 | SampdoriavFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-10-17 | GenkvStandardPro League · Belgium | 4–2 | Pro League · Belgium |
| 2010-10-17 | OberhausenvMunich 18602. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-10-17 | Willem IIvPSV EindhovenEredivisie · Netherlands | 2–4 | Eredivisie · Netherlands |
| 2010-10-17 | LarisavAsteras TripolisSuper League · Greece | 0–2 | Super League · Greece |
| 2010-10-17 | GranadavVallecanoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-10-17 | CordobavElcheLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-10-17 | GalatasarayvAnkaragucuSüper Lig · Turkey | 2–4 | Süper Lig · Turkey |
| 2010-10-17 | LorientvValenciennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-10-17 | LyonvLilleLigue 1 · France | 3–1 | Ligue 1 · France |
| 2010-10-17 | CesenavParmaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-10-16 | ForfarvAyrLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-10-16 | ExetervCarlisleLeague One · England | 2–1 | League One · England |
| 2010-10-16 | HuescavCartagenaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-10-16 | Villarreal BvCeltaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2010-10-16 | PeterborovSwindonLeague One · England | 5–4 | League One · England |
| 2010-10-16 | MontpelliervSochauxLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-10-16 | BarcelonavValenciaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-10-16 | Ath MadridvGetafeLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-10-16 | NewcastlevWiganPremier League · England | 2–2 | Premier League · England |
| 2010-10-16 | WesterlovMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-10-16 | ReadingvSwanseaChampionship · England | 0–1 | Championship · England |
| 2010-10-16 | HibernianvKilmarnockPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-10-16 | AldershotvMorecambeLeague Two · England | 2–1 | League Two · England |
| 2010-10-16 | DunfermlinevRoss CountyChampionship · Scotland | 3–2 | Championship · Scotland |
| 2010-10-16 | AccringtonvRotherhamLeague Two · England | 2–3 | League Two · England |
| 2010-10-16 | TamworthvRushden & DNational League · England | 1–2 | National League · England |
| 2010-10-16 | CrotonevPiacenzaSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-10-16 | Sheffield UnitedvBurnleyChampionship · England | 3–3 | Championship · England |
| 2010-10-16 | PanioniosvErgotelisSuper League · Greece | 0–1 | Super League · Greece |
| 2010-10-16 | MarseillevNancyLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-10-16 | MortonvQueen of SthChampionship · Scotland | 2–0 | Championship · Scotland |
| 2010-10-16 | Schalke 04vStuttgartBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2010-10-16 | Annan AthleticvAlbion RvsLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2010-10-16 | YorkvBath CityNational League · England | 1–1 | National League · England |
| 2010-10-16 | GrimsbyvSouthportNational League · England | 1–1 | National League · England |
| 2010-10-16 | MansfieldvDarlingtonNational League · England | 1–1 | National League · England |
| 2010-10-16 | VicenzavAlbinoleffeSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-10-16 | MiddlesbroughvLeedsChampionship · England | 1–2 | Championship · England |
| 2010-10-16 | RangersvMotherwellPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2010-10-16 | SassuolovNovaraSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-10-16 | WycombevChesterfieldLeague Two · England | 1–2 | League Two · England |
| 2010-10-16 | St MirrenvHamiltonPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2010-10-16 | Aston VillavChelseaPremier League · England | 0–0 | Premier League · England |
| 2010-10-16 | DerbyvPrestonChampionship · England | 3–0 | Championship · England |
| 2010-10-16 | StevenagevBurtonLeague Two · England | 2–1 | League Two · England |
| 2010-10-16 | AltrinchamvFleetwood TownNational League · England | 1–0 | National League · England |