| 2005-10-22 | BlackpoolvBrentfordLeague One · England | 0–0 | League One · England |
| 2005-10-22 | GalatasarayvDenizlisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2005-10-22 | Crystal PalacevBurnleyChampionship · England | 2–0 | Championship · England |
| 2005-10-22 | StenhousemuirvQueens ParkLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2005-10-22 | ArbroathvAlbion RvsLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2005-10-22 | LutonvPlymouthChampionship · England | 1–1 | Championship · England |
| 2005-10-22 | RotherhamvSwanseaLeague One · England | 2–2 | League One · England |
| 2005-10-22 | MetzvLyonLigue 1 · France | 0–4 | Ligue 1 · France |
| 2005-10-22 | MansfieldvBarnetLeague Two · England | 4–0 | League Two · England |
| 2005-10-22 | AnkaragucuvAnkarasporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2005-10-22 | LincolnvWycombeLeague Two · England | 1–2 | League Two · England |
| 2005-10-22 | PeterheadvAlloaLeague One · Scotland | 3–1 | League One · Scotland |
| 2005-10-22 | ClydevRoss CountyChampionship · Scotland | 1–0 | Championship · Scotland |
| 2005-10-22 | ArezzovCatanzaroSerie B · Italy | 1–0 | Serie B · Italy |
| 2005-10-22 | Cercle BruggevRoeselarePro League · Belgium | 2–2 | Pro League · Belgium |
| 2005-10-22 | Queen of SthvSt JohnstoneChampionship · Scotland | 1–3 | Championship · Scotland |
| 2005-10-22 | Aston VillavWiganPremier League · England | 0–2 | Premier League · England |
| 2005-10-22 | Man UnitedvTottenhamPremier League · England | 1–1 | Premier League · England |
| 2005-10-22 | SwindonvScunthorpeLeague One · England | 1–1 | League One · England |
| 2005-10-22 | Airdrie UtdvStranraerChampionship · Scotland | 1–0 | Championship · Scotland |
| 2005-10-22 | MessinavAscoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2005-10-22 | BerwickvEast FifeLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2005-10-22 | AberdeenvHibernianPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2005-10-22 | Raith RvsvMortonLeague One · Scotland | 1–2 | League One · Scotland |
| 2005-10-22 | IraklisvAtromitosSuper League · Greece | 2–0 | Super League · Greece |
| 2005-10-22 | WesterlovLokerenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2005-10-22 | MillwallvSouthamptonChampionship · England | 0–2 | Championship · England |
| 2005-10-22 | StockportvNorthamptonLeague Two · England | 4–2 | League Two · England |
| 2005-10-22 | VicenzavTernanaSerie B · Italy | 2–1 | Serie B · Italy |
| 2005-10-22 | StokevReadingChampionship · England | 0–1 | Championship · England |
| 2005-10-22 | St MirrenvDundeeChampionship · Scotland | 0–0 | Championship · Scotland |
| 2005-10-22 | TranmerevColchesterLeague One · England | 0–0 | League One · England |
| 2005-10-22 | MontrosevElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2005-10-22 | Bayern MunichvDuisburgBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2005-10-22 | FalkirkvDundee UnitedPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2005-10-22 | CrotonevAtalantaSerie B · Italy | 1–0 | Serie B · Italy |
| 2005-10-22 | GrimsbyvLeyton OrientLeague Two · England | 0–1 | League Two · England |
| 2005-10-22 | ForfarvGretnaLeague One · Scotland | 1–3 | League One · Scotland |
| 2005-10-22 | FiorentinavParmaSerie A · Italy | 4–1 | Serie A · Italy |
| 2005-10-22 | OldhamvBristol CityLeague One · England | 4–3 | League One · England |
| 2005-10-22 | SouthendvBarnsleyLeague One · England | 1–1 | League One · England |
| 2005-10-22 | NurnbergvBielefeldBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2005-10-22 | Rushden & DvShrewsburyLeague Two · England | 3–0 | League Two · England |
| 2005-10-22 | StirlingvPartickLeague One · Scotland | 1–2 | League One · Scotland |
| 2005-10-22 | BenficavEst AmadoraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2005-10-22 | YeovilvNott'm ForestLeague One · England | 3–0 | League One · England |
| 2005-10-22 | SpartavRoda JCEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2005-10-22 | BlackburnvBirminghamPremier League · England | 2–0 | Premier League · England |
| 2005-10-22 | NAC BredavTwenteEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2005-10-22 | HamiltonvBrechinChampionship · Scotland | 3–0 | Championship · Scotland |