| 2000-10-21 | La CorunavMallorcaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2000-10-21 | LouvieroisevBeverenPro League · Belgium | 2–3 | Pro League · Belgium |
| 2000-10-21 | NorthamptonvOldhamLeague One · England | 2–1 | League One · England |
| 2000-10-21 | Bristol CityvReadingLeague One · England | 4–0 | League One · England |
| 2000-10-21 | TenerifevBetisLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-10-21 | TranmerevWest BromChampionship · England | 2–2 | Championship · England |
| 2000-10-21 | NantesvRennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-10-21 | Crystal PalacevPortsmouthChampionship · England | 2–3 | Championship · England |
| 2000-10-21 | ChesterfieldvBrightonLeague Two · England | 1–0 | League Two · England |
| 2000-10-21 | KidderminstervExeterLeague Two · England | 0–0 | League Two · England |
| 2000-10-21 | GueugnonvLorientLigue 2 · France | 1–1 | Ligue 2 · France |
| 2000-10-21 | BradfordvIpswichPremier League · England | 0–2 | Premier League · England |
| 2000-10-21 | CaenvChateaurouxLigue 2 · France | 1–1 | Ligue 2 · France |
| 2000-10-21 | MortonvFalkirkChampionship · Scotland | 0–4 | Championship · Scotland |
| 2000-10-21 | StockportvBoltonChampionship · England | 4–3 | Championship · England |
| 2000-10-21 | GentvLiersePro League · Belgium | 2–3 | Pro League · Belgium |
| 2000-10-21 | SwindonvBristol RvsLeague One · England | 1–3 | League One · England |
| 2000-10-21 | StokevMillwallLeague One · England | 3–2 | League One · England |
| 2000-10-21 | BordeauxvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-10-21 | U.Las PalmasvFerrolLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2000-10-21 | Ath MadridvElcheLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2000-10-21 | ShrewsburyvLincolnLeague Two · England | 3–2 | League Two · England |
| 2000-10-21 | WiganvPort ValeLeague One · England | 1–0 | League One · England |
| 2000-10-21 | GerminalvWesterloPro League · Belgium | 3–1 | Pro League · Belgium |
| 2000-10-21 | MouscronvAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2000-10-21 | GenkvHarelbekePro League · Belgium | 4–0 | Pro League · Belgium |
| 2000-10-21 | West HamvArsenalPremier League · England | 1–2 | Premier League · England |
| 2000-10-21 | BesiktasvGalatasaraySüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2000-10-21 | GuingampvStrasbourgLigue 1 · France | 2–1 | Ligue 1 · France |
| 2000-10-21 | LutonvBrentfordLeague One · England | 3–1 | League One · England |
| 2000-10-21 | QPRvBurnleyChampionship · England | 0–1 | Championship · England |
| 2000-10-21 | Bayern MunichvMunich 1860Bundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2000-10-21 | CharltonvMiddlesbroughPremier League · England | 1–0 | Premier League · England |
| 2000-10-21 | AyrvAlloaChampionship · Scotland | 3–1 | Championship · Scotland |
| 2000-10-21 | AberdeenvDunfermlinePremiership · Scotland | 0–0 | Premiership · Scotland |
| 2000-10-21 | BlackburnvGrimsbyChampionship · England | 2–0 | Championship · England |
| 2000-10-21 | LensvSedanLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-10-21 | LokerenvAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2000-10-21 | CelticvDundee UnitedPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2000-10-21 | NimesvMartiguesLigue 2 · France | 2–0 | Ligue 2 · France |
| 2000-10-21 | WasquehalvMontpellierLigue 2 · France | 1–1 | Ligue 2 · France |
| 2000-10-21 | HerthavCottbusBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2000-10-21 | CreteilvCannesLigue 2 · France | 3–1 | Ligue 2 · France |
| 2000-10-21 | Man UnitedvLeedsPremier League · England | 3–0 | Premier League · England |
| 2000-10-21 | WrexhamvSwanseaLeague One · England | 1–0 | League One · England |
| 2000-10-21 | ScunthorpevDarlingtonLeague Two · England | 1–1 | League Two · England |
| 2000-10-21 | WolfsburgvFC KolnBundesliga · Germany | 6–0 | Bundesliga · Germany |
| 2000-10-21 | GenclerbirligivBursasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2000-10-21 | NewcastlevEvertonPremier League · England | 0–1 | Premier League · England |
| 2000-10-21 | MilanvJuventusSerie A · Italy | 2–2 | Serie A · Italy |