| 2021-12-22 | HeraclesvCambuurEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-12-22 | AjaxvFor SittardEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-12-22 | NapolivSpeziaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-12-22 | Willem IIvNijmegenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-12-22 |  MonacovRennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-12-22 | BordeauxvLilleLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-12-22 | IntervTorinoSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-12-22 | EmpolivMilanSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-12-22 | GaziantepvAlanyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-12-22 | HataysporvKonyasporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2021-12-22 |  Singaporev IndonesiaAFF Championship | 1–1 | AFF Championship |
| 2021-12-22 | RomavSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-12-22 | St JohnstonevRoss CountyPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-12-22 | Shandong TaishanvChangchun YataiSuper League · China | 2–1 | Super League · China |
| 2021-12-22 | SassuolovBolognaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-12-22 | CowdenbeathvEdinburgh CityLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2021-12-22 | MontrosevPeterheadLeague One · Scotland | 2–0 | League One · Scotland |
| 2021-12-21 | VitessevZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-12-21 | Paris FCvAmiensLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-12-21 | StirlingvElginLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2021-12-21 | AuxerrevLe HavreLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-12-21 | BuyuksehyrvGiresunsporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-12-21 | Qingdao FCvDalian ProSuper League · China | 1–2 | Super League · China |
| 2021-12-21 | AjacciovGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-12-21 | AZ AlkmaarvGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-12-21 | SevillavBarcelonaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-12-21 | Quevilly RouenvCaenLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-12-21 | CangzhouvTianjin Jinmen TigerSuper League · China | 2–1 | Super League · China |
| 2021-12-21 | SochauxvValenciennesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-12-21 | Chongqing Liangjiang AthleticvWuhan FCSuper League · China | 0–0 | Super League · China |
| 2021-12-21 | Ad. DemirsporvGalatasaraySüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-12-21 | GenoavAtalantaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-12-21 | AntalyasporvKasimpasaSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-12-21 | NimesvToulouseLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-12-21 | GuingampvDunkerqueLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-12-21 | NancyvDijonLigue 2 · France | 0–3 | Ligue 2 · France |
| 2021-12-21 | VillarrealvAlavesLa Liga · Spain | 5–2 | La Liga · Spain |
| 2021-12-21 | RodezvBastiaLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-12-21 | NiortvPau FCLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-12-21 | AltayvTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-12-21 | JuventusvCagliariSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-12-21 | Henan Songshan LongmenvShanghai ShenhuaSuper League · China | 2–0 | Super League · China |
| 2021-12-20 | FulhamvSheffield UnitedChampionship · England | 0–1 | Championship · England |
| 2021-12-20 | U Craiova 1948vMioveniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-12-20 | LevantevValenciaLa Liga · Spain | 3–4 | La Liga · Spain |
| 2021-12-20 | Din. BucurestivFarul ConstantaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-12-20 | AEKvOFI CreteSuper League · Greece | 1–2 | Super League · Greece |
| 2021-12-20 | ArisvIonikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-12-19 | BoavistavMoreirensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-12-19 | WaalwijkvPSV EindhovenEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |