| 2022-03-13 | LyonvRennesLigue 1 · France | 2–4 | Ligue 1 · France |
| 2022-03-04 | LorientvLyonLigue 1 · France | 1–4 | Ligue 1 · France |
| 2022-02-27 | LyonvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-19 | LensvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2022-02-12 | LyonvNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-05 |  MonacovLyonLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-01 | LyonvMarseilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-01-21 | LyonvSt EtienneLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-01-16 | TroyesvLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-01-09 | LyonvParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-22 | LyonvMetzLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-12 | LillevLyonLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-12-05 | BordeauxvLyonLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-12-01 | LyonvReimsLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-11-28 | MontpelliervLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-11-07 | RennesvLyonLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-10-30 | LyonvLensLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-10-24 | NicevLyonLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-10-16 | LyonvMonacoLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-03 | St EtiennevLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-09-25 | LyonvLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-09-22 | LyonvTroyesLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-09-19 | Paris SGvLyonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-09-12 | LyonvStrasbourgLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-08-27 | NantesvLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-08-22 | LyonvClermontLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-08-15 | AngersvLyonLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-08-07 | LyonvBrestLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-05-23 | LyonvNiceLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-05-16 | NimesvLyonLigue 1 · France | 2–5 | Ligue 1 · France |
| 2021-05-08 | LyonvLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-05-02 | MonacovLyonLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-04-25 | LyonvLilleLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-04-18 | NantesvLyonLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-04-11 | LyonvAngersLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-04-03 | LensvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-21 | LyonvParis SGLigue 1 · France | 2–4 | Ligue 1 · France |
| 2021-03-12 | ReimsvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-03 | LyonvRennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-02-28 | MarseillevLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-02-19 | BrestvLyonLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-02-13 | LyonvMontpellierLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-02-06 | LyonvStrasbourgLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-02-03 | DijonvLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-29 | LyonvBordeauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-01-24 | St EtiennevLyonLigue 1 · France | 0–5 | Ligue 1 · France |
| 2021-01-17 | LyonvMetzLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-09 | RennesvLyonLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-01-06 | LyonvLensLigue 1 · France | 3–2 | Ligue 1 · France |
| 2020-12-23 | LyonvNantesLigue 1 · France | 3–0 | Ligue 1 · France |