| 2022-01-22 | HoffenheimvDortmundBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2022-01-15 | Union BerlinvHoffenheimBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-01-08 | HoffenheimvAugsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-12-18 | HoffenheimvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-12-15 | LeverkusenvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-12-11 | FreiburgvHoffenheimBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-12-04 | HoffenheimvEin FrankfurtBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-11-27 | Greuther FurthvHoffenheimBundesliga · Germany | 3–6 | Bundesliga · Germany |
| 2021-11-20 | HoffenheimvRB LeipzigBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-11-06 | BochumvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-10-29 | HoffenheimvHerthaBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-10-23 | Bayern MunichvHoffenheimBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-10-15 | HoffenheimvFC KolnBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2021-10-02 | StuttgartvHoffenheimBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-09-25 | HoffenheimvWolfsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-09-18 | BielefeldvHoffenheimBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-09-11 | HoffenheimvMainzBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-08-27 | DortmundvHoffenheimBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-08-22 | HoffenheimvUnion BerlinBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-08-14 | AugsburgvHoffenheimBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2021-05-22 | HoffenheimvHerthaBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-05-15 | BielefeldvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-05-08 | HoffenheimvSchalke 04Bundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2021-04-24 | FreiburgvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-04-21 | HoffenheimvM'gladbachBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-04-16 | RB LeipzigvHoffenheimBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-04-12 | HoffenheimvLeverkusenBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-04-03 | AugsburgvHoffenheimBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-03-21 | HoffenheimvMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-03-14 | StuttgartvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-03-06 | HoffenheimvWolfsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-02-28 | Union BerlinvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-02-21 | HoffenheimvWerder BremenBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-02-13 | DortmundvHoffenheimBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-02-07 | HoffenheimvEin FrankfurtBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-01-30 | Bayern MunichvHoffenheimBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-01-24 | HoffenheimvFC KolnBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-01-19 | HerthavHoffenheimBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2021-01-16 | HoffenheimvBielefeldBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-01-09 | Schalke 04vHoffenheimBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-01-02 | HoffenheimvFreiburgBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2020-12-19 | M'gladbachvHoffenheimBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2020-12-16 | HoffenheimvRB LeipzigBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2020-12-13 | LeverkusenvHoffenheimBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2020-12-07 | HoffenheimvAugsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2020-11-29 | MainzvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2020-11-21 | HoffenheimvStuttgartBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2020-11-08 | WolfsburgvHoffenheimBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2020-11-02 | HoffenheimvUnion BerlinBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2020-10-25 | Werder BremenvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |