| 2022-08-21 | EmpolivFiorentinaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-08-14 | SpeziavEmpoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-05-21 | AtalantavEmpoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2022-05-14 | EmpolivSalernitanaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-05-06 | IntervEmpoliSerie A · Italy | 4–2 | Serie A · Italy |
| 2022-05-01 | EmpolivTorinoSerie A · Italy | 1–3 | Serie A · Italy |
| 2022-04-24 | EmpolivNapoliSerie A · Italy | 3–2 | Serie A · Italy |
| 2022-04-16 | UdinesevEmpoliSerie A · Italy | 4–1 | Serie A · Italy |
| 2022-04-09 | EmpolivSpeziaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-04-03 | FiorentinavEmpoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-03-20 | EmpolivVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-03-12 | MilanvEmpoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-03-06 | GenoavEmpoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-02-26 | EmpolivJuventusSerie A · Italy | 2–3 | Serie A · Italy |
| 2022-02-19 | SampdoriavEmpoliSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-02-13 | EmpolivCagliariSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-06 | BolognavEmpoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-01-23 | EmpolivRomaSerie A · Italy | 2–4 | Serie A · Italy |
| 2022-01-16 | VeneziavEmpoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-01-09 | EmpolivSassuoloSerie A · Italy | 1–5 | Serie A · Italy |
| 2022-01-06 | LaziovEmpoliSerie A · Italy | 3–3 | Serie A · Italy |
| 2021-12-22 | EmpolivMilanSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-12-19 | SpeziavEmpoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-12-12 | NapolivEmpoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-12-06 | EmpolivUdineseSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-12-02 | TorinovEmpoliSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-11-27 | EmpolivFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-11-22 | VeronavEmpoliSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-11-05 | EmpolivGenoaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-10-31 | SassuolovEmpoliSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-10-27 | EmpolivInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-10-23 | SalernitanavEmpoliSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-10-17 | EmpolivAtalantaSerie A · Italy | 1–4 | Serie A · Italy |
| 2021-10-03 | RomavEmpoliSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-09-26 | EmpolivBolognaSerie A · Italy | 4–2 | Serie A · Italy |
| 2021-09-22 | CagliarivEmpoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-09-19 | EmpolivSampdoriaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-09-11 | EmpolivVeneziaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-08-28 | JuventusvEmpoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-08-21 | EmpolivLazioSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-05-10 | EmpolivLecceSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-05-07 | SalernitanavEmpoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-05-04 | EmpolivCosenzaSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-05-01 | AscolivEmpoliSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-04-27 | EmpolivChievoSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-04-17 | EmpolivBresciaSerie B · Italy | 4–2 | Serie B · Italy |
| 2021-04-13 | CremonesevEmpoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-04-09 | ReggianavEmpoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-03-20 | EmpolivVirtus EntellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-03-16 | EmpolivPordenoneSerie B · Italy | 1–0 | Serie B · Italy |