| 2010-10-19 | Nott'm ForestvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2010-10-19 | DijonvVannesLigue 2 · France | 4–1 | Ligue 2 · France |
| 2010-10-19 | IstresvLe HavreLigue 2 · France | 0–2 | Ligue 2 · France |
| 2010-10-19 | MillwallvPortsmouthChampionship · England | 0–1 | Championship · England |
| 2010-10-19 | DoncastervDerbyChampionship · England | 2–3 | Championship · England |
| 2010-10-19 | SedanvTroyesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2010-10-19 | ClermontvLavalLigue 2 · France | 2–0 | Ligue 2 · France |
| 2010-10-19 | NimesvEvian Thonon GaillardLigue 2 · France | 1–3 | Ligue 2 · France |
| 2010-10-19 | GrenoblevMetzLigue 2 · France | 1–0 | Ligue 2 · France |
| 2010-10-18 | BlackburnvSunderlandPremier League · England | 0–0 | Premier League · England |
| 2010-10-18 | PadovavCittadellaSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-10-18 | HerculesvVillarrealLa Liga · Spain | 2–2 | La Liga · Spain |
| 2010-10-18 | BoulognevNantesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2010-10-18 | EmpolivSienaSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-10-18 | BielefeldvDuisburg2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2010-10-18 | KonyasporvFenerbahceSüper Lig · Turkey | 1–4 | Süper Lig · Turkey |
| 2010-10-17 | HeraclesvNijmegenEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-10-17 | AachenvIngolstadt2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-10-17 |  Dominican Republicv DominicaCFU Caribbean Cup qualification | 0–1 | CFU Caribbean Cup qualification |
| 2010-10-17 | LensvRennesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-10-17 | Ath BilbaovZaragozaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-10-17 | CagliarivInterSerie A · Italy | 0–1 | Serie A · Italy |
| 2010-10-17 | TenerifevNumanciaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-10-17 | Sp GijonvSevillaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-10-17 | EvertonvLiverpoolPremier League · England | 2–0 | Premier League · England |
| 2010-10-17 | GroningenvHeerenveenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-10-17 | KayserisporvSivassporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2010-10-17 | AtromitosvOlympiakos VolouSuper League · Greece | 2–2 | Super League · Greece |
| 2010-10-17 | CottbusvPaderborn2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2010-10-17 | CataniavNapoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-10-17 | BarivLazioSerie A · Italy | 0–2 | Serie A · Italy |
| 2010-10-17 | SantandervAlmeriaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-10-17 | PalermovBolognaSerie A · Italy | 4–1 | Serie A · Italy |
| 2010-10-17 | KerkyravKavalaSuper League · Greece | 1–1 | Super League · Greece |
| 2010-10-17 | JuventusvLecceSerie A · Italy | 4–0 | Serie A · Italy |
| 2010-10-17 | MallorcavEspanolLa Liga · Spain | 0–1 | La Liga · Spain |
| 2010-10-17 | ValladolidvLas PalmasLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2010-10-17 | La CorunavOsasunaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-10-17 | NicevSt EtienneLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-10-17 | RodavVitesseEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2010-10-17 | LevantevSociedadLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-10-17 |  Saint Luciav CuraçaoCFU Caribbean Cup qualification | 2–2 | CFU Caribbean Cup qualification |
| 2010-10-17 | Cercle BruggevAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2010-10-17 | BresciavUdineseSerie A · Italy | 0–1 | Serie A · Italy |
| 2010-10-17 | IraklisvPanserraikosSuper League · Greece | 1–1 | Super League · Greece |
| 2010-10-17 | BlackpoolvMan CityPremier League · England | 2–3 | Premier League · England |
| 2010-10-17 | HoffenheimvM'gladbachBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2010-10-17 | ArisvAEKSuper League · Greece | 0–4 | Super League · Greece |
| 2010-10-17 |  Surinamev GuyanaCFU Caribbean Cup qualification | 0–2 | CFU Caribbean Cup qualification |
| 2010-10-17 | GenclerbirligivAntalyasporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |