| 2010-10-23 | TorinovFrosinoneSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-10-23 | GraafschapvHeraclesEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-10-23 | Ein FrankfurtvSchalke 04Bundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-10-23 | CheltenhamvPort ValeLeague Two · England | 0–0 | League Two · England |
| 2010-10-23 | CartagenavAlcorconLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-10-23 | BuryvSouthendLeague Two · England | 1–0 | League Two · England |
| 2010-10-23 | NancyvLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-10-23 | DundeevDunfermlineChampionship · Scotland | 2–2 | Championship · Scotland |
| 2010-10-23 | ModenavSassuoloSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-10-23 |  MonacovValenciennesLigue 1 · France | 0–2 | Ligue 1 · France |
| 2010-10-23 | BrechinvAirdrie UtdLeague One · Scotland | 3–1 | League One · Scotland |
| 2010-10-23 | NurnbergvWolfsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-10-23 | StirlingvPartickChampionship · Scotland | 4–2 | Championship · Scotland |
| 2010-10-23 | RennesvMontpellierLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-10-23 | AberdeenvHibernianPremiership · Scotland | 4–2 | Premiership · Scotland |
| 2010-10-23 | BrightonvYeovilLeague One · England | 2–0 | League One · England |
| 2010-10-23 | StenhousemuirvDumbartonLeague One · Scotland | 4–0 | League One · Scotland |
| 2010-10-23 | BrentfordvPeterboroLeague One · England | 2–1 | League One · England |
| 2010-10-23 | LiersevWaregemPro League · Belgium | 0–0 | Pro League · Belgium |
| 2010-10-23 | RegginavEmpoliSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-10-23 | HamiltonvSt JohnstonePremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-10-23 | LivingstonvPeterheadLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-10-23 | BurtonvBradfordLeague Two · England | 3–0 | League Two · England |
| 2010-10-23 | WiganvBoltonPremier League · England | 1–1 | Premier League · England |
| 2010-10-23 | DoncastervSheffield UnitedChampionship · England | 2–0 | Championship · England |
| 2010-10-23 | CeltavGranadaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-10-23 | CowdenbeathvMortonChampionship · Scotland | 2–2 | Championship · Scotland |
| 2010-10-23 | HerefordvAccringtonLeague Two · England | 1–1 | League Two · England |
| 2010-10-23 | Raith RvsvRoss CountyChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-10-23 | GironavValladolidLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-10-23 | St TruidenvCharleroiPro League · Belgium | 3–2 | Pro League · Belgium |
| 2010-10-23 | AyrvAlloaLeague One · Scotland | 2–1 | League One · Scotland |
| 2010-10-23 | NijmegenvGroningenEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-10-23 | Cercle BruggevEupenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-10-23 | ChelseavWolvesPremier League · England | 2–0 | Premier League · England |
| 2010-10-23 | SunderlandvAston VillaPremier League · England | 1–0 | Premier League · England |
| 2010-10-23 | St EtiennevCaenLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-10-23 | FiorentinavBariSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-10-23 | M'gladbachvWerder BremenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2010-10-23 | Munich 1860vBielefeld2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-10-23 | MotherwellvDundee UnitedPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-10-23 | AtromitosvXanthiSuper League · Greece | 1–1 | Super League · Greece |
| 2010-10-23 | ChesterfieldvShrewsburyLeague Two · England | 4–3 | League Two · England |
| 2010-10-23 | KilmarnockvInverness CPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-10-23 | AntalyasporvKonyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2010-10-23 | PiacenzavAtalantaSerie B · Italy | 3–2 | Serie B · Italy |
| 2010-10-23 | Nott'm ForestvIpswichChampionship · England | 2–0 | Championship · England |
| 2010-10-23 | Sheffield WedsvBournemouthLeague One · England | 1–1 | League One · England |
| 2010-10-23 | WatfordvScunthorpeChampionship · England | 0–2 | Championship · England |
| 2010-10-23 | SetubalvGuimaraesPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |