| 2010-10-24 | EspanolvLevanteLa Liga · Spain | 2–1 | La Liga · Spain |
| 2010-10-24 | CelticvRangersPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2010-10-24 | PaderbornvFortuna Dusseldorf2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2010-10-24 | BochumvAachen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2010-10-24 | UdinesevPalermoSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-10-23 | BordeauxvBrestLigue 1 · France | 0–2 | Ligue 1 · France |
| 2010-10-23 | WalsallvTranmereLeague One · England | 1–4 | League One · England |
| 2010-10-23 | Las PalmasvAlbaceteLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-10-23 | Real MadridvSantanderLa Liga · Spain | 6–1 | La Liga · Spain |
| 2010-10-23 | PadovavPescaraSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-10-23 | SwanseavLeicesterChampionship · England | 2–0 | Championship · England |
| 2010-10-23 | AscolivCittadellaSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-10-23 | RochdalevDag and RedLeague One · England | 3–2 | League One · England |
| 2010-10-23 | Asteras TripolisvIraklisSuper League · Greece | 0–0 | Super League · Greece |
| 2010-10-23 | PlymouthvHuddersfieldLeague One · England | 2–1 | League One · England |
| 2010-10-23 | Queen of SthvFalkirkChampionship · Scotland | 1–5 | Championship · Scotland |
| 2010-10-23 | TottenhamvEvertonPremier League · England | 1–1 | Premier League · England |
| 2010-10-23 | SwindonvLeyton OrientLeague One · England | 2–2 | League One · England |
| 2010-10-23 | HartlepoolvBristol RvsLeague One · England | 2–2 | League One · England |
| 2010-10-23 | VallecanovRecreativoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-10-23 | ValenciavMallorcaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-10-23 | Barcelona BvHuescaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2010-10-23 | West HamvNewcastlePremier League · England | 1–2 | Premier League · England |
| 2010-10-23 | HannovervFC KolnBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-10-23 | BarnetvMacclesfieldLeague Two · England | 1–0 | League Two · England |
| 2010-10-23 | ElchevPonferradinaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-10-23 | SochauxvToulouseLigue 1 · France | 1–3 | Ligue 1 · France |
| 2010-10-23 | ZaragozavBarcelonaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2010-10-23 | RotherhamvWycombeLeague Two · England | 3–4 | League Two · England |
| 2010-10-23 | BirminghamvBlackpoolPremier League · England | 2–0 | Premier League · England |
| 2010-10-23 | Milton Keynes DonsvExeterLeague One · England | 1–0 | League One · England |
| 2010-10-23 | CoventryvBarnsleyChampionship · England | 3–0 | Championship · England |
| 2010-10-23 | LensvNiceLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-10-23 | West BromvFulhamPremier League · England | 2–1 | Premier League · England |
| 2010-10-23 | HeartsvSt MirrenPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2010-10-23 | CrewevAldershotLeague Two · England | 3–1 | League Two · England |
| 2010-10-23 | CarlislevCharltonLeague One · England | 3–4 | League One · England |
| 2010-10-23 | HeerenveenvVVV VenloEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-10-23 | MechelenvGerminalPro League · Belgium | 5–1 | Pro League · Belgium |
| 2010-10-23 | NorwichvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2010-10-23 | BuyuksehyrvGaziantepsporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2010-10-23 | TrabzonsporvGenclerbirligiSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2010-10-23 | FreiburgvKaiserslauternBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-10-23 | Pacos FerreiravBeira MarPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-10-23 | PrestonvCrystal PalaceChampionship · England | 4–3 | Championship · England |
| 2010-10-23 | OxfordvNorthamptonLeague Two · England | 3–1 | League Two · England |
| 2010-10-23 | ColchestervNotts CountyLeague One · England | 2–1 | League One · England |
| 2010-10-23 | Sp BragavOlhanensePrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-10-23 | Olympiakos VolouvLarisaSuper League · Greece | 1–1 | Super League · Greece |
| 2010-10-23 | SouthamptonvOldhamLeague One · England | 2–1 | League One · England |