| 2021-11-20 | BradfordvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2021-11-20 | LeicestervChelseaPremier League · England | 0–3 | Premier League · England |
| 2021-11-20 | DunfermlinevAyrChampionship · Scotland | 3–0 | Championship · Scotland |
| 2021-11-20 | ValenciennesvGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-11-20 | AlmeriavValladolidLaLiga 2 · Spain | 3–1 | LaLiga 2 · Spain |
| 2021-11-20 | WaregemvGentPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-11-20 | St MirrenvLivingstonPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-11-20 | Malmo FFvHackenAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-11-20 | SalzburgvAdmiraAustrian Bundesliga · Austria | 0–0 | Austrian Bundesliga · Austria |
| 2021-11-20 | AZ AlkmaarvNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-11-20 | U Craiova 1948vCFR ClujLiga I · Romania | 0–2 | Liga I · Romania |
| 2021-11-20 | IonikosvAsteras TripolisSuper League Greece · Greece | 1–1 | Super League Greece · Greece |
| 2021-11-20 | WalsallvRochdaleLeague Two · England | 0–0 | League Two · England |
| 2021-11-20 | CeltavVillarrealLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2021-11-20 | Werder BremenvSchalke 042. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-11-20 | NancyvRodezLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-11-20 | SK RapidvAltachAustrian Bundesliga · Austria | 1–0 | Austrian Bundesliga · Austria |
| 2021-11-20 | Raith RvsvMortonChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-11-20 | RennesvMontpellierLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-11-20 | VikingvHaugesundEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-11-20 | Kashima AntlersvOita TrinitaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-11-20 | HartlepoolvForest GreenLeague Two · England | 1–3 | League Two · England |
| 2021-11-20 | StevenagevColchesterLeague Two · England | 1–0 | League Two · England |
| 2021-11-20 | Paris SGvNantesLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-11-20 | CrewevGillinghamLeague One · England | 2–0 | League One · England |
| 2021-11-20 | ReadingvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2021-11-20 | PartickvHamiltonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-11-20 | Stal MielecvLechia GdanskEkstraklasa · Poland | 3–3 | Ekstraklasa · Poland |
| 2021-11-20 | FalkirkvMontroseLeague One · Scotland | 0–1 | League One · Scotland |
| 2021-11-20 | ArisvGianninaSuper League Greece · Greece | 0–5 | Super League Greece · Greece |
| 2021-11-20 | CharltonvPlymouthLeague One · England | 2–0 | League One · England |
| 2021-11-20 | DoncastervLincolnLeague One · England | 0–0 | League One · England |
| 2021-11-20 | Atletico-MGvJuventudeBrasileirão · Brazil | 2–0 | Brasileirão · Brazil |
| 2021-11-20 | LaziovJuventusSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-11-20 | NorwichvSouthamptonPremier League · England | 2–1 | Premier League · England |
| 2021-11-20 | WeymouthvAltrinchamNational League · England | 1–4 | National League · England |
| 2021-11-20 | Rosario CentralvAtl. TucumanLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-11-20 | ClydevEast FifeLeague One · Scotland | 3–1 | League One · Scotland |
| 2021-11-20 | CheltenhamvShrewsburyLeague One · England | 2–1 | League One · England |
| 2021-11-20 | GiresunsporvYeni MalatyasporSüper Lig · Türkiye | 1–0 | Süper Lig · Türkiye |
| 2021-11-20 | SevillavAlavesLaLiga · Spain | 2–2 | LaLiga · Spain |
| 2021-11-20 | StirlingvEdinburgh CityLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2021-11-20 | DarmstadtvSt Pauli2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-11-20 | Aston VillavBrightonPremier League · England | 2–0 | Premier League · England |
| 2021-11-20 | Gamba OsakavNagoya GrampusJ1 League · Japan | 1–3 | J1 League · Japan |
| 2021-11-20 | HarrogatevSalfordLeague Two · England | 0–2 | League Two · England |
| 2021-11-20 | OldhamvPort ValeLeague Two · England | 3–2 | League Two · England |
| 2021-11-20 | BastiavNiortLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-11-20 | MalagavLas PalmasLaLiga 2 · Spain | 2–1 | LaLiga 2 · Spain |
| 2021-11-20 | MansfieldvScunthorpeLeague Two · England | 3–1 | League Two · England |