| 2021-11-20 | Krylya SovetovvUralRussian Premier League · Russia | 1–1 | Russian Premier League · Russia |
| 2021-11-20 | HataysporvAntalyasporSüper Lig · Türkiye | 3–1 | Süper Lig · Türkiye |
| 2021-11-20 | AccringtonvSheffield WedsLeague One · England | 2–3 | League One · England |
| 2021-11-20 | JagielloniavWislaEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-11-20 | Lech PoznanvPiast GliwiceEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-11-20 | Vegalta SendaivShonan BellmareJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-11-20 | SionvZurichSwiss Super League · Switzerland | 0–1 | Swiss Super League · Switzerland |
| 2021-11-20 | HeraclesvFor SittardEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-11-20 | BuyuksehyrvSivassporSüper Lig · Türkiye | 2–1 | Süper Lig · Türkiye |
| 2021-11-20 | HuddersfieldvWest BromChampionship · England | 1–0 | Championship · England |
| 2021-11-20 | FortalezavPalmeirasBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-20 | TernanavCittadellaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-20 | Sheffield UnitedvCoventryChampionship · England | 0–0 | Championship · England |
| 2021-11-20 | Le HavrevAmiensLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-11-20 | RiedvHartbergAustrian Bundesliga · Austria | 1–0 | Austrian Bundesliga · Austria |
| 2021-11-20 | M'gladbachvGreuther FurthBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-11-20 | PerugiavCrotoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-11-20 | Fleetwood TownvMorecambeLeague One · England | 1–2 | League One · England |
| 2021-11-20 | Lokomotiv MoscowvAkhmat GroznyRussian Premier League · Russia | 1–2 | Russian Premier League · Russia |
| 2021-11-20 | VicenzavBresciaSerie B · Italy | 2–3 | Serie B · Italy |
| 2021-11-20 | Dundee UnitedvAberdeenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-11-20 | DunkerquevAjaccioLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-11-20 | Leyton OrientvSuttonLeague Two · England | 4–1 | League Two · England |
| 2021-11-20 | PeterheadvQueens ParkLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-11-20 | BurnleyvCrystal PalacePremier League · England | 3–3 | Premier League · England |
| 2021-11-20 | NimesvQuevilly RouenLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-11-20 | AtalantavSpeziaSerie A · Italy | 5–2 | Serie A · Italy |
| 2021-11-20 | LiverpoolvArsenalPremier League · England | 4–0 | Premier League · England |
| 2021-11-20 | RotherhamvCambridgeLeague One · England | 3–1 | League One · England |
| 2021-11-20 | HoffenheimvRB LeipzigBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-11-20 | SwanseavBlackpoolChampionship · England | 1–1 | Championship · England |
| 2021-11-20 | FC TokyovTokushimaJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-11-20 | WokingvStockportNational League · England | 1–2 | National League · England |
| 2021-11-20 | Dag and RedvYeovilNational League · England | 0–1 | National League · England |
| 2021-11-20 | WolvesvWest HamPremier League · England | 1–0 | Premier League · England |
| 2021-11-20 | StokevPeterboroChampionship · England | 2–0 | Championship · England |
| 2021-11-20 | FiorentinavMilanSerie A · Italy | 4–3 | Serie A · Italy |
| 2021-11-20 | HullvBirminghamChampionship · England | 2–0 | Championship · England |
| 2021-11-20 | Urawa RedsvYokohama F. MarinosJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-11-20 | StandardvEupenPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-11-20 | Hansa RostockvErzgebirge Aue2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-11-20 | Philadelphia UnionvNew York Red BullsMLS · United States | 0–0 | MLS · United States |
| 2021-11-20 | SolihullvChesterfieldNational League · England | 0–2 | National League · England |
| 2021-11-20 | WycombevBoltonLeague One · England | 1–0 | League One · England |
| 2021-11-20 | Boreham WoodvMaidenheadNational League · England | 4–0 | National League · England |
| 2021-11-20 | StranraervElginLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-11-20 | Newport CountyvSwindonLeague Two · England | 1–2 | League Two · England |
| 2021-11-20 | Sparta RotterdamvTwenteEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-11-20 | PortsmouthvAFC WimbledonLeague One · England | 2–1 | League One · England |
| 2021-11-20 | Volos NFCvOFI CreteSuper League Greece · Greece | 0–2 | Super League Greece · Greece |