| 2010-10-30 | FrosinonevTriestinaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-10-30 | EvertonvStokePremier League · England | 1–0 | Premier League · England |
| 2010-10-30 | PortsmouthvNott'm ForestChampionship · England | 2–1 | Championship · England |
| 2010-10-30 | PonferradinavLas PalmasLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2010-10-30 | GaziantepsporvKarabuksporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-10-30 | MotherwellvHamiltonPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-10-30 | AldershotvBuryLeague Two · England | 1–3 | League Two · England |
| 2010-10-30 | Notts CountyvSouthamptonLeague One · England | 1–3 | League One · England |
| 2010-10-30 | EupenvLiersePro League · Belgium | 2–2 | Pro League · Belgium |
| 2010-10-30 | Newport CountyvKettering TownNational League · England | 1–2 | National League · England |
| 2010-10-30 | Leyton OrientvRochdaleLeague One · England | 2–1 | League One · England |
| 2010-10-30 | WycombevLincolnLeague Two · England | 2–2 | League Two · England |
| 2010-10-30 | LivornovRegginaSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-10-30 | Airdrie UtdvStenhousemuirLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-10-30 | CardiffvNorwichChampionship · England | 3–1 | Championship · England |
| 2010-10-30 | OldhamvPlymouthLeague One · England | 4–2 | League One · England |
| 2010-10-30 | BradfordvOxfordLeague Two · England | 5–0 | League Two · England |
| 2010-10-30 | BerwickvQueens ParkLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2010-10-30 | VVV VenlovGroningenEredivisie · Netherlands | 3–5 | Eredivisie · Netherlands |
| 2010-10-30 | Dundee UnitedvHibernianPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-10-30 | HistonvWrexhamNational League · England | 1–1 | National League · England |
| 2010-10-30 | ForfarvLivingstonLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-10-30 | LeicestervPrestonChampionship · England | 1–0 | Championship · England |
| 2010-10-30 | Werder BremenvNurnbergBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2010-10-30 | StranraervElginLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-10-30 | NorthamptonvGillinghamLeague Two · England | 2–1 | League Two · England |
| 2010-10-30 | St JohnstonevCelticPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2010-10-30 | TranmerevMilton Keynes DonsLeague One · England | 4–2 | League One · England |
| 2010-10-30 | HerculesvReal MadridLa Liga · Spain | 1–3 | La Liga · Spain |
| 2010-10-30 | ExetervBrentfordLeague One · England | 2–4 | League One · England |
| 2010-10-30 | ArisvAtromitosSuper League · Greece | 2–0 | Super League · Greece |
| 2010-10-30 | NAC BredavGraafschapEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-10-30 | Crystal PalacevSwanseaChampionship · England | 0–3 | Championship · England |
| 2010-10-30 | MortonvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-10-30 | Dag and RedvHartlepoolLeague One · England | 1–1 | League One · England |
| 2010-10-30 | TorquayvMorecambeLeague Two · England | 3–1 | League Two · England |
| 2010-10-30 | BrestvSt EtienneLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-10-30 | AuxerrevNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-10-30 | CharltonvSheffield WedsLeague One · England | 1–0 | League One · England |
| 2010-10-30 | Sheffield UnitedvCoventryChampionship · England | 0–1 | Championship · England |
| 2010-10-30 | WolvesvMan CityPremier League · England | 2–1 | Premier League · England |
| 2010-10-30 | DerbyvWatfordChampionship · England | 4–1 | Championship · England |
| 2010-10-30 | AFC WimbledonvDarlingtonNational League · England | 0–2 | National League · England |
| 2010-10-30 | AtalantavPadovaSerie B · Italy | 4–1 | Serie B · Italy |
| 2010-10-30 | PanathinaikosvOlympiakosSuper League · Greece | 2–1 | Super League · Greece |
| 2010-10-30 | ShrewsburyvBarnetLeague Two · England | 2–1 | League Two · England |
| 2010-10-30 | MansfieldvCrawley TownNational League · England | 1–4 | National League · England |
| 2010-10-30 | HeraclesvAjaxEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2010-10-30 | RangersvInverness CPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-10-30 | ScunthorpevLeedsChampionship · England | 1–4 | Championship · England |