| 2008-11-02 | TenerifevVallecanoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-11-02 | GalatasarayvGaziantepsporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2008-11-02 | AlavesvElcheLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2008-11-02 | M'gladbachvEin FrankfurtBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2008-11-02 | Roda JCvFeyenoordEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2008-11-02 | Est AmadoravBelenensesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2008-11-02 | BetisvLa CorunaLa Liga · Spain | 0–3 | La Liga · Spain |
| 2008-11-02 | IraklisvPAOKSuper League · Greece | 1–1 | Super League · Greece |
| 2008-11-02 | VitessevDen HaagEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2008-11-02 | BursasporvAnkarasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2008-11-02 | XerezvMurciaLa Liga 2 · Spain | 5–3 | La Liga 2 · Spain |
| 2008-11-02 | RennesvSochauxLigue 1 · France | 1–0 | Ligue 1 · France |
| 2008-11-02 | SampdoriavTorinoSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-11-02 | GerminalvAnderlechtPro League · Belgium | 1–3 | Pro League · Belgium |
| 2008-11-02 | IngolstadtvFreiburg2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2008-11-02 | St PaulivNurnberg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2008-11-02 | RecreativovGetafeLa Liga · Spain | 1–1 | La Liga · Spain |
| 2008-11-02 | AlicantevAlbaceteLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2008-11-02 | EspanolvOsasunaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2008-11-02 | AhlenvMainz2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2008-11-02 | HeartsvCelticPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2008-11-02 | UdinesevGenoaSerie A · Italy | 2–2 | Serie A · Italy |
| 2008-11-02 | ValladolidvSevillaLa Liga · Spain | 3–2 | La Liga · Spain |
| 2008-11-02 | EibarvLevanteLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2008-11-02 | OFIvXanthiSuper League · Greece | 0–2 | Super League · Greece |
| 2008-11-02 | BoltonvMan CityPremier League · England | 2–0 | Premier League · England |
| 2008-11-02 | GuimaraesvBenficaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2008-11-02 | Sp GijonvNumanciaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2008-11-02 | AtalantavLecceSerie A · Italy | 0–0 | Serie A · Italy |
| 2008-11-02 | AEKvAsteras TripolisSuper League · Greece | 2–1 | Super League · Greece |
| 2008-11-02 | LaziovCataniaSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-11-02 | KocaelisporvAnkaragucuSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2008-11-02 | CagliarivBolognaSerie A · Italy | 5–1 | Serie A · Italy |
| 2008-11-02 | AcademicavSp BragaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2008-11-02 | OsnabruckvAugsburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2008-11-02 | AlmeriavReal MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2008-11-02 | Le Havrev MonacoLigue 1 · France | 2–3 | Ligue 1 · France |
| 2008-11-02 | LeixoesvPacos FerreiraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2008-11-02 | CeltavSalamancaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-11-02 | PalermovChievoSerie A · Italy | 3–0 | Serie A · Italy |
| 2008-11-02 | DerbyvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2008-11-02 | LyonvLe MansLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-11-02 | Sevilla BvHerculesLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2008-11-02 | OlympiakosvErgotelisSuper League · Greece | 2–0 | Super League · Greece |
| 2008-11-02 | MilanvNapoliSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-11-02 | DortmundvBochumBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2008-11-02 | SivassporvDenizlisporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2008-11-02 | GenclerbirligivAntalyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2008-11-02 | UtrechtvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2008-11-02 | WaregemvGentPro League · Belgium | 0–2 | Pro League · Belgium |