| 2021-11-20 | ExetervCarlisleLeague Two · England | 2–1 | League Two · England |
| 2021-11-20 | Argentinos JrsvGodoy CruzLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-11-20 | Cerezo OsakavKawasaki FrontaleJ1 League · Japan | 1–4 | J1 League · Japan |
| 2021-11-20 | AlanyasporvBesiktasSüper Lig · Türkiye | 2–0 | Süper Lig · Türkiye |
| 2021-11-20 | Pau FCvGuingampLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-11-20 | FrosinonevLecceSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-11-20 | MotherwellvHeartsPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-11-20 | ForfarvCowdenbeathLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2021-11-20 | PrestonvCardiffChampionship · England | 1–2 | Championship · England |
| 2021-11-20 | PordenonevAscoliSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-11-20 | ToulousevSochauxLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-11-20 | Bristol CityvBlackburnChampionship · England | 1–1 | Championship · England |
| 2021-11-20 | Yokohama FCvVissel KobeJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-11-20 | Sporting Kansas CityvVancouver WhitecapsMLS · United States | 3–1 | MLS · United States |
| 2021-11-20 | Dover AthleticvHalifaxNational League · England | 1–3 | National League · England |
| 2021-11-20 | MiddlesbroughvMillwallChampionship · England | 1–1 | Championship · England |
| 2021-11-20 | WrexhamvWealdstoneNational League · England | 0–0 | National League · England |
| 2021-11-20 | LeverkusenvBochumBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-11-20 | KrasnodarvSpartak MoscowRussian Premier League · Russia | 2–1 | Russian Premier League · Russia |
| 2021-11-20 | Ath MadridvOsasunaLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2021-11-20 | BielefeldvWolfsburgBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-11-20 | Warta PoznanvWisla PlockEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-11-20 | KilmarnockvArbroathChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-11-20 | CaenvParis FCLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-11-20 | Airdrie UtdvCove RangersLeague One · Scotland | 0–2 | League One · Scotland |
| 2021-11-20 | WatfordvMan UnitedPremier League · England | 4–1 | Premier League · England |
| 2021-11-20 | Kashiwa ReysolvAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-11-20 | SpalvAlessandriaSerie B · Italy | 2–3 | Serie B · Italy |
| 2021-11-20 | Boca JuniorsvSarmiento JuninLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-11-20 | Sagan TosuvHokkaido Consadole SapporoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-11-20 | BarrowvCrawley TownLeague Two · England | 0–1 | League Two · England |
| 2021-11-20 | Bristol RvsvTranmereLeague Two · England | 2–2 | League Two · England |
| 2021-11-20 | Farul ConstantavUTA AradLiga I · Romania | 0–0 | Liga I · Romania |
| 2021-11-20 | Talleres CordobavVelez SarsfieldLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-11-20 | BarnetvTorquayNational League · England | 2–1 | National League · England |
| 2021-11-20 | OviedovAmorebietaLaLiga 2 · Spain | 2–0 | LaLiga 2 · Spain |
| 2021-11-20 | HamburgvRegensburg2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2021-11-20 | Shimizu S-PulsevSanfrecce HiroshimaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-11-20 | NewcastlevBrentfordPremier League · England | 3–3 | Premier League · England |
| 2021-11-20 | BromleyvKings LynnNational League · England | 3–2 | National League · England |
| 2021-11-20 | Milton Keynes DonsvBurtonLeague One · England | 1–0 | League One · England |
| 2021-11-20 | BarcelonavEspanolLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2021-11-20 | Kelty HeartsvStenhousemuirLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-11-20 | EastleighvNotts CountyNational League · England | 2–0 | National League · England |
| 2021-11-20 | SunderlandvIpswichLeague One · England | 2–0 | League One · England |
| 2021-11-20 | PSV EindhovenvVitesseEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-11-20 | Chapecoense-SCvGremioBrasileirão · Brazil | 1–3 | Brasileirão · Brazil |
| 2021-11-20 | StromsgodsetvMjondalenEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-11-20 | Union BerlinvHerthaBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-11-20 | Oud-Heverlee LeuvenvSeraingPro League · Belgium | 1–3 | Pro League · Belgium |