| 2010-10-30 | LorientvArlesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-10-30 | WaregemvLokerenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-10-30 | PartickvCowdenbeathChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-10-30 | Villarreal BvCartagenaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-10-30 | Port ValevCreweLeague Two · England | 2–1 | League Two · England |
| 2010-10-30 | KarlsruhevMunich 18602. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2010-10-30 | CaenvNancyLigue 1 · France | 2–3 | Ligue 1 · France |
| 2010-10-30 | CittadellavGrossetoSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-10-30 | St MirrenvAberdeenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-10-30 | HerthavIngolstadt2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2010-10-30 | GrimsbyvEastbourne BoroughNational League · England | 2–2 | National League · England |
| 2010-10-30 | Hayes & YeadingvAltrinchamNational League · England | 0–1 | National League · England |
| 2010-10-30 | BarcelonavSevillaLa Liga · Spain | 5–0 | La Liga · Spain |
| 2010-10-30 | WolfsburgvStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-10-30 | HuescavNumanciaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-10-30 | Rio AvevSp BragaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2010-10-30 | BournemouthvColchesterLeague One · England | 1–2 | League One · England |
| 2010-10-30 | ReadingvDoncasterChampionship · England | 4–3 | Championship · England |
| 2010-10-30 | WesterlovCercle BruggePro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-10-30 | Schalke 04vLeverkusenBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-10-30 | FulhamvWiganPremier League · England | 2–0 | Premier League · England |
| 2010-10-30 | HuddersfieldvWalsallLeague One · England | 1–0 | League One · England |
| 2010-10-30 | LyonvSochauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-10-30 | AcademicavPortoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2010-10-30 | Rushden & DvBarrowNational League · England | 5–0 | National League · England |
| 2010-10-30 | VicenzavVareseSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-10-30 | GatesheadvCambridgeNational League · England | 2–3 | National League · England |
| 2010-10-30 | StockportvHerefordLeague Two · England | 0–5 | League Two · England |
| 2010-10-30 | EmpolivCrotoneSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-10-30 | StevenagevChesterfieldLeague Two · England | 0–0 | League Two · England |
| 2010-10-30 | FalkirkvDundeeChampionship · Scotland | 3–3 | Championship · Scotland |
| 2010-10-30 | ValladolidvSalamancaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-10-30 | DumbartonvEast FifeLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-10-30 | PSV EindhovenvTwenteEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2010-10-30 | ToulousevLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-10-30 | BarnsleyvHullChampionship · England | 1–1 | Championship · England |
| 2010-10-30 | ArsenalvWest HamPremier League · England | 1–0 | Premier League · England |
| 2010-10-30 | LarisavXanthiSuper League · Greece | 3–0 | Super League · Greece |
| 2010-10-30 | Bristol RvsvCarlisleLeague One · England | 1–1 | League One · England |
| 2010-10-30 | SouthendvRotherhamLeague Two · England | 1–0 | League Two · England |
| 2010-10-30 | MilanvJuventusSerie A · Italy | 1–2 | Serie A · Italy |
| 2010-10-30 | NovaravAlbinoleffeSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-10-30 | PescaravModenaSerie B · Italy | 0–2 | Serie B · Italy |
| 2010-10-30 | AccringtonvCheltenhamLeague Two · England | 2–4 | League Two · England |
| 2010-10-30 | IpswichvMillwallChampionship · England | 2–0 | Championship · England |
| 2010-10-30 | ExcelsiorvHeerenveenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2010-10-30 | Ross CountyvQueen of SthChampionship · Scotland | 1–1 | Championship · Scotland |
| 2010-10-30 | LutonvBath CityNational League · England | 3–1 | National League · England |
| 2010-10-30 | EskisehirsporvAnkaragucuSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-10-30 | AlloavBrechinLeague One · Scotland | 2–2 | League One · Scotland |