| 2021-11-21 | StrasbourgvReimsLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-11-21 | KasimpasavKaragumrukSüper Lig · Türkiye | 1–3 | Süper Lig · Türkiye |
| 2021-11-21 | OostendevSt. GilloisePro League · Belgium | 1–7 | Pro League · Belgium |
| 2021-11-21 | AtromitosvPAOKSuper League Greece · Greece | 2–0 | Super League Greece · Greece |
| 2021-11-21 | Santos LagunavAtl. San LuisLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-11-21 | VarbergvAIKAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-11-21 | CorinthiansvSantosBrasileirão · Brazil | 2–0 | Brasileirão · Brazil |
| 2021-11-21 | ServettevGrasshoppersSwiss Super League · Switzerland | 3–2 | Swiss Super League · Switzerland |
| 2021-11-21 | Gornik Z.vLegiaEkstraklasa · Poland | 3–2 | Ekstraklasa · Poland |
| 2021-11-21 | A. KlagenfurtvAustria ViennaAustrian Bundesliga · Austria | 0–0 | Austrian Bundesliga · Austria |
| 2021-11-21 | HuescavIbizaLaLiga 2 · Spain | 0–0 | LaLiga 2 · Spain |
| 2021-11-21 | St TruidenvAntwerpPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-11-21 | RegginavCremoneseSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-11-21 | FK RostovvUfaRussian Premier League · Russia | 2–2 | Russian Premier League · Russia |
| 2021-11-21 | Arsenal SarandivNewells Old BoysLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-11-21 | GenoavRomaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-11-21 | SociedadvValenciaLaLiga · Spain | 0–0 | LaLiga · Spain |
| 2021-11-21 | CSKA MoscowvKhimkiRussian Premier League · Russia | 0–0 | Russian Premier League · Russia |
| 2021-11-21 | LuganovLuzernSwiss Super League · Switzerland | 3–1 | Swiss Super League · Switzerland |
| 2021-11-21 | ValerengavTromsoEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-11-21 | Bodo/GlimtvLillestromEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2021-11-21 | Randers FCvVejleDanish Superliga · Denmark | 4–1 | Danish Superliga · Denmark |
| 2021-11-21 | MainzvFC KolnBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-11-21 | Racing ClubvColon Santa FELiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-11-21 | FluminensevAmerica MGBrasileirão · Brazil | 2–0 | Brasileirão · Brazil |
| 2021-11-21 | Sturm GrazvLASKAustrian Bundesliga · Austria | 3–3 | Austrian Bundesliga · Austria |
| 2021-11-21 | FeyenoordvZwolleEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2021-11-21 | SalernitanavSampdoriaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-11-21 | ElchevBetisLaLiga · Spain | 0–3 | LaLiga · Spain |
| 2021-11-21 | FC ArgesvUniv. CraiovaLiga I · Romania | 3–2 | Liga I · Romania |
| 2021-11-21 | Man CityvEvertonPremier League · England | 3–0 | Premier League · England |
| 2021-11-21 | Termalica B-B.vLecznaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-11-21 | FCSBvFC BotosaniLiga I · Romania | 3–1 | Liga I · Romania |
| 2021-11-21 | PonferradinavSp GijonLaLiga 2 · Spain | 4–1 | LaLiga 2 · Spain |
| 2021-11-21 | IntervNapoliSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-11-21 | Atletico GOvCearaBrasileirão · Brazil | 1–1 | Brasileirão · Brazil |
| 2021-11-21 | SassuolovCagliariSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-11-21 | MoldevRosenborgEliteserien · Norway | 4–1 | Eliteserien · Norway |
| 2021-11-21 | ClermontvNiceLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-11-21 | Go Ahead EaglesvGroningenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-11-21 | Dynamo MoscowvArsenal TulaRussian Premier League · Russia | 5–1 | Russian Premier League · Russia |
| 2021-11-21 | NordsjaellandvSilkeborgDanish Superliga · Denmark | 1–1 | Danish Superliga · Denmark |
| 2021-11-21 | GranadavReal MadridLaLiga · Spain | 1–4 | LaLiga · Spain |
| 2021-11-21 | IngolstadtvKarlsruhe2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-11-21 | CambuurvUtrechtEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-11-21 | SiriusvGoteborgAllsvenskan · Sweden | 3–3 | Allsvenskan · Sweden |
| 2021-11-21 | PanetolikosvApollonSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2021-11-21 | CartagenavBurgosLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2021-11-21 | TenerifevAlcorconLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2021-11-20 | Cercle BruggevCharleroiPro League · Belgium | 1–2 | Pro League · Belgium |