| 2021-11-22 | Sociedad BvGironaLaLiga 2 · Spain | 1–2 | LaLiga 2 · Spain |
| 2021-11-22 | NorrkopingvDjurgardenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-11-22 | DijonvAuxerreLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-11-22 | SonderjyskevAalborgDanish Superliga · Denmark | 1–3 | Danish Superliga · Denmark |
| 2021-11-22 | Cruz AzulvMonterreyLiga MX · Mexico | 1–4 | Liga MX · Mexico |
| 2021-11-22 | VeronavEmpoliSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-11-22 | KayserisporvGoztepSüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2021-11-22 | PlatensevRiver PlateLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-11-22 | MiovenivGaz Metan MediasLiga I · Romania | 1–0 | Liga I · Romania |
| 2021-11-21 | FC CopenhagenvAarhusDanish Superliga · Denmark | 1–1 | Danish Superliga · Denmark |
| 2021-11-21 | Sarpsborg 08vOddEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-11-21 | SandefjordvBrannEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-11-21 | KonyasporvRizesporSüper Lig · Türkiye | 3–0 | Süper Lig · Türkiye |
| 2021-11-21 | WaalwijkvAjaxEredivisie · Netherlands | 0–5 | Eredivisie · Netherlands |
| 2021-11-21 | New York CityvAtlanta UtdMLS · United States | 2–0 | MLS · United States |
| 2021-11-21 | AltayvAd. DemirsporSüper Lig · Türkiye | 1–3 | Süper Lig · Türkiye |
| 2021-11-21 | BolognavVeneziaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-11-21 | HalmstadvElfsborgAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-11-21 | GalatasarayvFenerbahceSüper Lig · Türkiye | 1–2 | Süper Lig · Türkiye |
| 2021-11-21 | HeidenheimvHolstein Kiel2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-11-21 | Portland TimbersvMinnesota UnitedMLS · United States | 3–1 | MLS · United States |
| 2021-11-21 | BrestvLensLigue 1 · France | 4–0 | Ligue 1 · France |
| 2021-11-21 | Beerschot VAvGenkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-11-21 | TottenhamvLeedsPremier League · England | 2–1 | Premier League · England |
| 2021-11-21 | Central CordobavIndependienteLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-11-21 | DegerforsvHammarbyAllsvenskan · Sweden | 1–4 | Allsvenskan · Sweden |
| 2021-11-21 | StabaekvKristiansundEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2021-11-21 | Pogon SzczecinvSlask WroclawEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-11-21 | TolucavUNAM PumasLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-11-21 | InternacionalvFlamengo RJBrasileirão · Brazil | 1–2 | Brasileirão · Brazil |
| 2021-11-21 | PisavBeneventoSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-11-21 | BahiavCuiabaBrasileirão · Brazil | 0–0 | Brasileirão · Brazil |
| 2021-11-21 | DerbyvBournemouthChampionship · England | 3–2 | Championship · England |
| 2021-11-21 | MetzvBordeauxLigue 1 · France | 3–3 | Ligue 1 · France |
| 2021-11-21 | SochivRubin KazanRussian Premier League · Russia | 1–2 | Russian Premier League · Russia |
| 2021-11-21 | DresdenvFortuna Dusseldorf2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-11-21 | St. GallenvLausanneSwiss Super League · Switzerland | 0–1 | Swiss Super League · Switzerland |
| 2021-11-21 | GetafevCadizLaLiga · Spain | 4–0 | LaLiga · Spain |
| 2021-11-21 | FreiburgvEin FrankfurtBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-11-21 | ParmavCosenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-21 | PueblavGuadalajara ChivasLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-11-21 | TirolvWolfsberger ACAustrian Bundesliga · Austria | 5–1 | Austrian Bundesliga · Austria |
| 2021-11-21 | AnderlechtvKortrijkPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-11-21 | AEKvOlympiakosSuper League Greece · Greece | 2–3 | Super League Greece · Greece |
| 2021-11-21 | AngersvLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-11-21 | MidtjyllandvBrondbyDanish Superliga · Denmark | 1–2 | Danish Superliga · Denmark |
| 2021-11-21 | HeerenveenvWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-11-21 | MonzavComoSerie B · Italy | 3–2 | Serie B · Italy |
| 2021-11-21 | LugovEibarLaLiga 2 · Spain | 2–2 | LaLiga 2 · Spain |
| 2021-11-21 | TroyesvSt EtienneLigue 1 · France | 0–1 | Ligue 1 · France |