| 2000-11-05 | GroningenvAZ AlkmaarEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2000-11-05 | YianninavAthinaikosSuper League · Greece | 3–1 | Super League · Greece |
| 2000-11-05 | UdinesevLecceSerie A · Italy | 2–0 | Serie A · Italy |
| 2000-11-05 | Pacos FerreiravSp BragaPrimeira Liga · Portugal | 4–2 | Primeira Liga · Portugal |
| 2000-11-05 | BetisvMurciaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2000-11-05 | VeronavInterSerie A · Italy | 2–2 | Serie A · Italy |
| 2000-11-04 | Man CityvLeicesterPremier League · England | 0–1 | Premier League · England |
| 2000-11-04 | FulhamvHuddersfieldChampionship · England | 3–0 | Championship · England |
| 2000-11-04 | St JohnstonevDunfermlinePremiership · Scotland | 0–2 | Premiership · Scotland |
| 2000-11-04 | TottenhamvSunderlandPremier League · England | 2–1 | Premier League · England |
| 2000-11-04 | CowdenbeathvEast FifeLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2000-11-04 | CoventryvMan UnitedPremier League · England | 1–2 | Premier League · England |
| 2000-11-04 | NumanciavReal MadridLa Liga · Spain | 3–1 | La Liga · Spain |
| 2000-11-04 | CrewevWolvesChampionship · England | 2–0 | Championship · England |
| 2000-11-04 | CharltonvBradfordPremier League · England | 2–0 | Premier League · England |
| 2000-11-04 | Nott'm ForestvPrestonChampionship · England | 3–1 | Championship · England |
| 2000-11-04 | SouthendvMacclesfieldLeague Two · England | 3–1 | League Two · England |
| 2000-11-04 | AuxerrevParis SGLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-11-04 | East StirlingvDumbartonLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2000-11-04 | HamburgvFreiburgBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2000-11-04 | DenizlisporvIstanbulsporSüper Lig · Turkey | 0–4 | Süper Lig · Turkey |
| 2000-11-04 | ClydevInverness CChampionship · Scotland | 1–1 | Championship · Scotland |
| 2000-11-04 | EspanolvValenciaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2000-11-04 | OberhausenvMainz2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2000-11-04 | WatfordvGrimsbyChampionship · England | 4–0 | Championship · England |
| 2000-11-04 | NancyvGueugnonLigue 2 · France | 4–0 | Ligue 2 · France |
| 2000-11-04 | BordeauxvLilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-11-04 | TwentevPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2000-11-04 | RangersvSt MirrenPremiership · Scotland | 7–1 | Premiership · Scotland |
| 2000-11-04 | JaenvSevillaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2000-11-04 | HullvDarlingtonLeague Two · England | 2–0 | League Two · England |
| 2000-11-04 | AlloavAirdrieChampionship · Scotland | 2–0 | Championship · Scotland |
| 2000-11-04 | BlackpoolvShrewsburyLeague Two · England | 0–1 | League Two · England |
| 2000-11-04 | RotherhamvWiganLeague One · England | 1–1 | League One · England |
| 2000-11-04 | FarensevBoavistaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2000-11-04 | LeedsvLiverpoolPremier League · England | 4–3 | Premier League · England |
| 2000-11-04 | Port ValevMillwallLeague One · England | 1–1 | League One · England |
| 2000-11-04 | GuingampvSedanLigue 1 · France | 0–3 | Ligue 1 · France |
| 2000-11-04 | SouthamptonvChelseaPremier League · England | 3–2 | Premier League · England |
| 2000-11-04 | MiddlesbroughvArsenalPremier League · England | 0–1 | Premier League · England |
| 2000-11-04 | NicevSochauxLigue 2 · France | 2–2 | Ligue 2 · France |
| 2000-11-04 | CreteilvMontpellierLigue 2 · France | 1–1 | Ligue 2 · France |
| 2000-11-04 | NAC BredavNijmegenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2000-11-04 | StirlingvStenhousemuirLeague One · Scotland | 2–3 | League One · Scotland |
| 2000-11-04 | HeartsvAberdeenPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2000-11-04 | FiorentinavPerugiaSerie A · Italy | 3–4 | Serie A · Italy |
| 2000-11-04 | CaenvLe MansLigue 2 · France | 0–2 | Ligue 2 · France |
| 2000-11-04 | MarseillevRennesLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-11-04 | BlackburnvStockportChampionship · England | 2–1 | Championship · England |
| 2000-11-04 | LensvBastiaLigue 1 · France | 4–0 | Ligue 1 · France |