| 2021-12-26 | OldhamvScunthorpeLeague Two · England | 1–3 | League Two · England |
| 2021-12-26 | BromleyvSouthendNational League · England | 1–1 | National League · England |
| 2021-12-26 | LincolnvMilton Keynes DonsLeague One · England | 2–3 | League One · England |
| 2021-12-26 | FenerbahcevYeni MalatyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-12-26 | Dundee UnitedvHibernianPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2021-12-26 | St JohnstonevCelticPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2021-12-26 | HuddersfieldvBlackpoolChampionship · England | 3–2 | Championship · England |
| 2021-12-26 | MotherwellvLivingstonPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-12-26 | NorwichvArsenalPremier League · England | 0–5 | Premier League · England |
| 2021-12-26 | CheltenhamvPlymouthLeague One · England | 0–2 | League One · England |
| 2021-12-26 | AccringtonvRotherhamLeague One · England | 1–0 | League One · England |
| 2021-12-26 | DunfermlinevArbroathChampionship · Scotland | 0–3 | Championship · Scotland |
| 2021-12-26 | OostendevGenkPro League · Belgium | 0–4 | Pro League · Belgium |
| 2021-12-26 | MansfieldvHartlepoolLeague Two · England | 3–2 | League Two · England |
| 2021-12-26 | St. GilloisevGentPro League · Belgium | 0–0 | Pro League · Belgium |
| 2021-12-26 | Shandong TaishanvHebeiSuper League · China | 2–0 | Super League · China |
| 2021-12-25 | Qingdao FCvShanghai ShenhuaSuper League · China | 0–1 | Super League · China |
| 2021-12-25 | TrabzonsporvBuyuksehyrSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-12-25 | KasimpasavAltaySüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-12-25 | Chongqing Liangjiang AthleticvTianjin Jinmen TigerSuper League · China | 0–1 | Super League · China |
| 2021-12-25 | Henan Songshan LongmenvDalian ProSuper League · China | 1–0 | Super League · China |
| 2021-12-25 |  Singaporev IndonesiaAFF Championship | 2–4 | AFF Championship |
| 2021-12-25 | GalatasarayvAntalyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-12-25 | GiresunsporvHataysporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-12-25 | CangzhouvWuhan FCSuper League · China | 2–0 | Super League · China |
| 2021-12-23 |  Vietnamv ThailandAFF Championship | 0–2 | AFF Championship |
| 2021-12-23 | PSV EindhovenvGo Ahead EaglesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-12-23 | Yeni MalatyasporvKayserisporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-12-23 | Sparta RotterdamvWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-12-23 | BesiktasvGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-12-22 | Ath BilbaovReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-12-22 | LyonvMetzLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-22 | VeronavFiorentinaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-12-22 | UtrechtvTwenteEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-12-22 | HeerenveenvFeyenoordEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2021-12-22 | TroyesvBrestLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-22 | HebeivGuangzhou CitySuper League · China | 1–1 | Super League · China |
| 2021-12-22 | VeneziavLazioSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-12-22 | LorientvParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-22 | MarseillevReimsLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-12-22 | Beijing GuoanvShenzhenSuper League · China | 2–2 | Super League · China |
| 2021-12-22 | GranadavAth MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-12-22 | KaragumrukvFenerbahceSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-12-22 | SivassporvRizesporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-12-22 | NicevLensLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-12-22 | MontpelliervAngersLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-12-22 | Guangzhou FCvShanghai PortSuper League · China | 0–0 | Super League · China |
| 2021-12-22 | St EtiennevNantesLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-12-22 | HibernianvAberdeenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-12-22 | St MirrenvCelticPremiership · Scotland | 0–0 | Premiership · Scotland |