| 2021-11-23 | SuttonvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2021-11-23 | TranmerevBradfordLeague Two · England | 2–1 | League Two · England |
| 2021-11-23 | CoventryvBirminghamChampionship · England | 0–0 | Championship · England |
| 2021-11-23 | LincolnvPortsmouthLeague One · England | 0–3 | League One · England |
| 2021-11-23 | WeymouthvWokingNational League · England | 2–3 | National League · England |
| 2021-11-23 | PlymouthvWycombeLeague One · England | 0–3 | League One · England |
| 2021-11-23 | CarlislevHarrogateLeague Two · England | 0–2 | League Two · England |
| 2021-11-23 | BurtonvAccringtonLeague One · England | 4–0 | League One · England |
| 2021-11-23 | Crawley TownvNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2021-11-23 | AFC WimbledonvCreweLeague One · England | 3–2 | League One · England |
| 2021-11-23 | MiddlesbroughvPrestonChampionship · England | 1–2 | Championship · England |
| 2021-11-23 | Dag and RedvEastleighNational League · England | 0–1 | National League · England |
| 2021-11-23 | Dover AthleticvWealdstoneNational League · England | 2–3 | National League · England |
| 2021-11-23 | NorthamptonvOldhamLeague Two · England | 2–1 | League Two · England |
| 2021-11-23 | Port ValevWalsallLeague Two · England | 0–1 | League Two · England |
| 2021-11-23 | ElginvEdinburgh CityLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-11-23 | SolihullvGrimsbyNational League · England | 2–0 | National League · England |
| 2021-11-23 | CambridgevWiganLeague One · England | 2–2 | League One · England |
| 2021-11-23 | Boreham WoodvNotts CountyNational League · England | 1–1 | National League · England |
| 2021-11-23 | AldershotvTorquayNational League · England | 1–0 | National League · England |
| 2021-11-23 | GillinghamvCheltenhamLeague One · England | 0–2 | League One · England |
| 2021-11-23 | BlackpoolvWest BromChampionship · England | 0–0 | Championship · England |
| 2021-11-23 | BromleyvYeovilNational League · England | 1–2 | National League · England |
| 2021-11-23 | Atletico GOvJuventudeBrasileirão · Brazil | 1–1 | Brasileirão · Brazil |
| 2021-11-23 | BoltonvDoncasterLeague One · England | 3–0 | League One · England |
| 2021-11-23 | ReadingvSheffield UnitedChampionship · England | 0–1 | Championship · England |
| 2021-11-23 | RochdalevStevenageLeague Two · England | 2–2 | League Two · England |
| 2021-11-23 | IpswichvRotherhamLeague One · England | 0–2 | League One · England |
| 2021-11-23 | ShrewsburyvSunderlandLeague One · England | 1–1 | League One · England |
| 2021-11-23 | SwindonvHartlepoolLeague Two · England | 3–1 | League Two · England |
| 2021-11-23 | AldosivivSan LorenzoLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-11-23 | HuracanvPatronatoLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-11-23 | SalfordvBristol RvsLeague Two · England | 1–1 | League Two · England |
| 2021-11-23 | MorecambevCharltonLeague One · England | 2–2 | League One · England |
| 2021-11-23 | Sheffield WedsvMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2021-11-23 | Gimnasia L.P.vTalleres CordobaLiga Profesional · Argentina | 5–2 | Liga Profesional · Argentina |
| 2021-11-23 | ScunthorpevLeyton OrientLeague Two · England | 1–1 | League Two · England |
| 2021-11-23 | Nott'm ForestvLutonChampionship · England | 0–0 | Championship · England |
| 2021-11-23 | ColchestervExeterLeague Two · England | 3–1 | League Two · England |
| 2021-11-23 | StockportvKings LynnNational League · England | 5–0 | National League · England |
| 2021-11-22 | CracoviavRakowEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-11-22 | OstersundsvMjallbyAllsvenskan · Sweden | 0–2 | Allsvenskan · Sweden |
| 2021-11-22 | TorinovUdineseSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-11-22 | TrabzonsporvGaziantepSüper Lig · Türkiye | 3–0 | Süper Lig · Türkiye |
| 2021-11-22 | FC VoluntarivDin. BucurestiLiga I · Romania | 2–1 | Liga I · Romania |
| 2021-11-22 | ZaragozavLeganesLaLiga 2 · Spain | 0–2 | LaLiga 2 · Spain |
| 2021-11-22 | LamiavPanathinaikosSuper League Greece · Greece | 1–3 | Super League Greece · Greece |
| 2021-11-22 | ZaglebievRadomiak RadomEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-11-22 | VallecanovMallorcaLaLiga · Spain | 3–1 | LaLiga · Spain |
| 2021-11-22 | OrebrovKalmarAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |