| 2021-01-06 | Wurzburger KickersvSt Pauli2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-06 | AtalantavParmaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-01-06 | TrabzonsporvGoztepSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-01-06 | MetzvBordeauxLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-01-06 | TorinovVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-01-06 | EupenvGenkPro League · Belgium | 1–4 | Pro League · Belgium |
| 2021-01-06 | GenclerbirligivHataysporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-01-06 | AntalyasporvKaragumrukSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-01-06 | SassuolovGenoaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-06 | LaziovFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-06 | LyonvLensLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-01-06 | Sport RecifevFortalezaSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-01-06 | CagliarivBeneventoSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-01-06 | ApollonvPanathinaikosSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-06 | SampdoriavInterSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-06 | CrotonevRomaSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-01-06 | Lorientv MonacoLigue 1 · France | 2–5 | Ligue 1 · France |
| 2021-01-06 | Atl. TucumanvColon Santa FECopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2021-01-06 | StrasbourgvNimesLigue 1 · France | 5–0 | Ligue 1 · France |
| 2021-01-06 | NantesvRennesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-01-06 | LarisavGianninaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-01-06 | CoritibavGoiasSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-01-06 | Botafogo RJvAthletico-PRSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-01-06 | St EtiennevParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-01-06 | AEKvPanetolikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-01-06 | BrestvNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-01-06 | Asteras TripolisvOlympiakosSuper League · Greece | 0–4 | Super League · Greece |
| 2021-01-06 | ReimsvDijonLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-01-06 | DenizlisporvKayserisporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-01-06 | MilanvJuventusSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-01-06 | NapolivSpeziaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-01-06 | BuyuksehyrvErzurum BBSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-01-05 | GaziantepvAnkaragucuSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-01-05 | ValenciennesvNancyLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-01-05 | AjacciovPau FCLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-01-05 | HuracanvArgentinos JrsCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-01-05 | KonyasporvGalatasaraySüper Lig · Turkey | 4–3 | Süper Lig · Turkey |
| 2021-01-05 | MansfieldvSalfordLeague Two · England | 2–1 | League Two · England |
| 2021-01-05 | AuxerrevCaenLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-05 | GuingampvAmiensLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-01-05 | Godoy CruzvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-01-05 | ChamblyvLe HavreLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-01-05 | WeymouthvYeovilNational League · England | 0–3 | National League · England |
| 2021-01-05 | TroyesvChateaurouxLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-01-05 | ToulousevParis FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-05 | Yeni MalatyasporvSivassporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-01-05 | RodezvNiortLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-05 | ClermontvGrenobleLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-01-05 | Talleres CordobavBanfieldCopa De La Liga Profesional · Argentina | 3–2 | Copa De La Liga Profesional · Argentina |
| 2021-01-05 | SochauxvDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |