| 2021-01-09 | Port ValevGrimsbyLeague Two · England | 3–0 | League Two · England |
| 2021-01-09 | GenoavBolognaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-01-09 | GrenoblevAuxerreLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-01-09 | BoavistavSanta ClaraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-01-09 | LensvStrasbourgLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-09 | MetzvNiceLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-01-09 | SunderlandvHullLeague One · England | 1–1 | League One · England |
| 2021-01-09 | Paris SGvBrestLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-01-09 | SivassporvGaziantepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-01-09 | SevillavSociedadLa Liga · Spain | 3–2 | La Liga · Spain |
| 2021-01-09 | PueblavGuadalajara ChivasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-01-09 | SuttonvAltrinchamNational League · England | 2–2 | National League · England |
| 2021-01-09 |  MonacovAngersLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-01-09 | LeverkusenvWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-01-09 | Velez SarsfieldvGodoy CruzCopa De La Liga Profesional · Argentina | 3–2 | Copa De La Liga Profesional · Argentina |
| 2021-01-09 | OsasunavReal MadridLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-01-09 | PanetolikosvOlympiakosSuper League · Greece | 1–2 | Super League · Greece |
| 2021-01-08 | Atletico GOvVascoSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-01-08 | ChateaurouxvGuingampLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-01-08 | KarlsruhevGreuther Furth2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-01-08 | NacionalvSp LisbonPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-01-08 | Pau FCvChamblyLigue 2 · France | 1–3 | Ligue 2 · France |
| 2021-01-08 | M'gladbachvBayern MunichBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-01-08 | Rio AvevPortimonensePrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-01-08 | CeltavVillarrealLa Liga · Spain | 0–4 | La Liga · Spain |
| 2021-01-08 | SandhausenvHeidenheim2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-01-08 | ZaragozavLogronesLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-01-08 | FamalicaovPortoPrimeira Liga · Portugal | 1–4 | Primeira Liga · Portugal |
| 2021-01-08 | NiortvAmiensLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-01-08 | CharltonvAccringtonLeague One · England | 0–2 | League One · England |
| 2021-01-08 | BenficavTondelaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-01-08 | NancyvRodezLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-01-08 | DunkerquevTroyesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-01-08 | Le HavrevValenciennesLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-01-08 | SochauxvClermontLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-01-08 | Paris FCvAjaccioLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-07 | BragantinovSao PauloSerie A · Brazil | 4–2 | Serie A · Brazil |
| 2021-01-07 | FenerbahcevAlanyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-01-07 | ArisvVolos NFCSuper League · Greece | 2–0 | Super League · Greece |
| 2021-01-07 | Flamengo RJvFluminenseSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-01-07 | AtromitosvPAOKSuper League · Greece | 3–2 | Super League · Greece |
| 2021-01-07 | OFI CretevLamiaSuper League · Greece | 2–0 | Super League · Greece |
| 2021-01-07 | CearavInternacionalSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-01-07 | Sp BragavMaritimoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-01-06 | Ath BilbaovBarcelonaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-01-06 | BesiktasvRizesporSüper Lig · Turkey | 6–0 | Süper Lig · Turkey |
| 2021-01-06 | MarseillevMontpellierLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-01-06 | LillevAngersLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-01-06 | BolognavUdineseSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-01-06 | GremiovBahiaSerie A · Brazil | 2–1 | Serie A · Brazil |