| 2021-01-16 | UtrechtvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-01-16 | CardiffvNorwichChampionship · England | 1–2 | Championship · England |
| 2021-01-16 | West HamvBurnleyPremier League · England | 1–0 | Premier League · England |
| 2021-01-16 | BlackburnvStokeChampionship · England | 1–1 | Championship · England |
| 2021-01-16 | LeedsvBrightonPremier League · England | 0–1 | Premier League · England |
| 2021-01-16 | AmiensvLe HavreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-01-16 | JuarezvClub TijuanaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-01-16 | RodezvPau FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-16 | CelticvLivingstonPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-01-16 | WolfsburgvRB LeipzigBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-01-16 | MonzavCosenzaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-01-16 | GrimsbyvSouthendLeague Two · England | 0–0 | League Two · England |
| 2021-01-16 | BarrowvScunthorpeLeague Two · England | 1–0 | League Two · England |
| 2021-01-16 | Fleetwood TownvPortsmouthLeague One · England | 0–1 | League One · England |
| 2021-01-16 | AlloavHeartsChampionship · Scotland | 1–3 | Championship · Scotland |
| 2021-01-16 | Leyton OrientvMorecambeLeague Two · England | 2–0 | League Two · England |
| 2021-01-16 | BarnsleyvSwanseaChampionship · England | 0–2 | Championship · England |
| 2021-01-16 | MarseillevNimesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-01-16 | PeterborovMilton Keynes DonsLeague One · England | 3–0 | League One · England |
| 2021-01-16 | Nott'm ForestvMillwallChampionship · England | 3–1 | Championship · England |
| 2021-01-16 | AZ AlkmaarvDen HaagEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-01-16 | DortmundvMainzBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-01-16 | PalmeirasvGremioBrasileirão · Brazil | 1–1 | Brasileirão · Brazil |
| 2021-01-16 | AuxerrevChateaurouxLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-01-16 | MiddlesbroughvBirminghamChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | Din. BucurestivChindia TargovisteLiga I · Romania | 0–1 | Liga I · Romania |
| 2021-01-16 | BuyuksehyrvSivassporSüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2021-01-16 | WolvesvWest BromPremier League · England | 2–3 | Premier League · England |
| 2021-01-16 | Ross CountyvAberdeenPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2021-01-16 | RegginavLecceSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-01-16 | Bristol RvsvCharltonLeague One · England | 0–1 | League One · England |
| 2021-01-16 | BournemouthvLutonChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | KonyasporvGoztepSüper Lig · Türkiye | 2–3 | Süper Lig · Türkiye |
| 2021-01-16 | BurtonvIpswichLeague One · England | 0–1 | League One · England |
| 2021-01-16 | StevenagevTranmereLeague Two · England | 0–0 | League Two · England |
| 2021-01-16 | AccringtonvGillinghamLeague One · England | 0–1 | League One · England |
| 2021-01-16 | AFC WimbledonvSunderlandLeague One · England | 0–3 | League One · England |
| 2021-01-16 | CittadellavAscoliSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-01-16 | HannovervSt Pauli2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-01-16 | Newport CountyvSalfordLeague Two · England | 0–0 | League Two · England |
| 2021-01-16 | DerbyvRotherhamChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | WalsallvOldhamLeague Two · England | 1–1 | League Two · England |
| 2021-01-16 | TroyesvSochauxLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-01-16 | HullvBlackpoolLeague One · England | 1–1 | League One · England |
| 2021-01-16 | WrexhamvDover AthleticNational League · England | 3–1 | National League · England |
| 2021-01-16 | OostendevKortrijkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-01-16 | WatfordvHuddersfieldChampionship · England | 2–0 | Championship · England |
| 2021-01-15 | Greuther FurthvPaderborn2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-15 | Union BerlinvLeverkusenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-15 | ChievovVirtus EntellaSerie B · Italy | 2–1 | Serie B · Italy |