| 2010-11-06 | East FifevAlloaLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-11-06 | Bath CityvAltrinchamNational League · England | 2–2 | National League · England |
| 2010-11-06 | CoventryvLeedsChampionship · England | 2–3 | Championship · England |
| 2010-11-06 | St JohnstonevKilmarnockPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2010-11-06 | AugsburgvBielefeld2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2010-11-06 | AlbinoleffevSassuoloSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-11-06 | Man UnitedvWolvesPremier League · England | 2–1 | Premier League · England |
| 2010-11-06 | VallecanovValladolidLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2010-11-06 | XerezvRecreativoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-11-06 | MortonvDunfermlineChampionship · Scotland | 2–1 | Championship · Scotland |
| 2010-11-06 | HamiltonvDundee UnitedPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-11-06 | BolognavLecceSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-11-06 | BarrowvNewport CountyNational League · England | 2–1 | National League · England |
| 2010-11-06 | XanthivIraklisSuper League · Greece | 2–2 | Super League · Greece |
| 2010-11-06 | Raith RvsvQueen of SthChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-11-06 | VaresevCittadellaSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-11-06 | GraafschapvNijmegenEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2010-11-06 | PiacenzavVicenzaSerie B · Italy | 4–1 | Serie B · Italy |
| 2010-11-06 | BordeauxvValenciennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-06 | CordobavHuescaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-11-06 | ModenavLivornoSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-11-06 | CowdenbeathvStirlingChampionship · Scotland | 5–1 | Championship · Scotland |
| 2010-11-06 | Sheffield UnitedvIpswichChampionship · England | 1–2 | Championship · England |
| 2010-11-06 | Inverness CvMotherwellPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-11-06 | RennesvLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-06 | ElginvAnnan AthleticLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2010-11-06 | Bristol CityvPrestonChampionship · England | 1–1 | Championship · England |
| 2010-11-06 | OlympiakosvPanioniosSuper League · Greece | 5–0 | Super League · Greece |
| 2010-11-06 | GroningenvNAC BredaEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2010-11-06 | QPRvReadingChampionship · England | 3–1 | Championship · England |
| 2010-11-06 | ArlesvCaenLigue 1 · France | 3–2 | Ligue 1 · France |
| 2010-11-06 | FalkirkvRoss CountyChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-11-06 | HeerenveenvHeraclesEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-11-06 | Queens ParkvStranraerLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2010-11-06 | BirminghamvWest HamPremier League · England | 2–2 | Premier League · England |
| 2010-11-06 | St TruidenvWaregemPro League · Belgium | 0–3 | Pro League · Belgium |
| 2010-11-06 | BlackburnvWiganPremier League · England | 2–1 | Premier League · England |
| 2010-11-06 | Ein FrankfurtvWolfsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2010-11-06 | PadovavEmpoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2010-11-06 | CelticvAberdeenPremiership · Scotland | 9–0 | Premiership · Scotland |
| 2010-11-06 | LiersevLokerenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2010-11-06 | BoltonvTottenhamPremier League · England | 4–2 | Premier League · England |
| 2010-11-06 | St EtiennevLorientLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-11-06 | StenhousemuirvBrechinLeague One · Scotland | 0–0 | League One · Scotland |
| 2010-11-06 | SunderlandvStokePremier League · England | 2–0 | Premier League · England |
| 2010-11-06 | AscolivNovaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-11-06 | SalamancavAlbaceteLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-11-06 | MontrosevAlbion RvsLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2010-11-06 |  Trinidad and Tobagov HaitiCFU Caribbean Cup qualification | 4–0 | CFU Caribbean Cup qualification |
| 2010-11-06 | DerbyvPortsmouthChampionship · England | 2–0 | Championship · England |