| 2008-11-15 | BrechinvEast FifeLeague One · Scotland | 2–1 | League One · Scotland |
| 2008-11-15 | AlicantevCordobaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2008-11-15 | MarseillevLorientLigue 1 · France | 2–3 | Ligue 1 · France |
| 2008-11-15 | RochdalevMacclesfieldLeague Two · England | 1–1 | League Two · England |
| 2008-11-15 | WeymouthvWrexhamNational League · England | 1–3 | National League · England |
| 2008-11-15 | LutonvDag and RedLeague Two · England | 2–1 | League Two · England |
| 2008-11-15 | CrewevLeyton OrientLeague One · England | 0–2 | League One · England |
| 2008-11-15 | GillinghamvRotherhamLeague Two · England | 4–0 | League Two · England |
| 2008-11-15 | Port ValevBrentfordLeague Two · England | 0–3 | League Two · England |
| 2008-11-15 | GimnasticvZaragozaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2008-11-15 | Sp LisbonvLeixoesPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2008-11-15 | West BromvChelseaPremier League · England | 0–3 | Premier League · England |
| 2008-11-15 | HistonvKettering TownNational League · England | 1–0 | National League · England |
| 2008-11-15 | SalernitanavRiminiSerie B · Italy | 2–3 | Serie B · Italy |
| 2008-11-15 | AvellinovBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2008-11-15 | SouthamptonvWolvesChampionship · England | 1–2 | Championship · England |
| 2008-11-15 | Le HavrevParis SGLigue 1 · France | 1–3 | Ligue 1 · France |
| 2008-11-15 | FalkirkvMotherwellPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2008-11-15 | KocaelisporvDenizlisporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2008-11-15 | HibernianvAberdeenPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2008-11-15 | HerthavHamburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2008-11-15 | Inverness CvHeartsPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2008-11-15 | StranraervAlloaLeague One · Scotland | 2–2 | League One · Scotland |
| 2008-11-15 | AccringtonvBournemouthLeague Two · England | 3–0 | League Two · England |
| 2008-11-15 | HartlepoolvMilton Keynes DonsLeague One · England | 1–3 | League One · England |
| 2008-11-15 | CarlislevBrightonLeague One · England | 3–1 | League One · England |
| 2008-11-15 | ValenciavSp GijonLa Liga · Spain | 2–3 | La Liga · Spain |
| 2008-11-15 | Le MansvValenciennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2008-11-15 | EibarvLas PalmasLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2008-11-15 | Eastbourne BoroughvWokingNational League · England | 0–0 | National League · England |
| 2008-11-15 | LivornovTrevisoSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-11-15 | BuryvGrimsbyLeague Two · England | 0–2 | League Two · England |
| 2008-11-15 | StevenagevNorthwichNational League · England | 1–1 | National League · England |
| 2008-11-15 | HoffenheimvWolfsburgBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2008-11-15 | BlackburnvSunderlandPremier League · England | 1–2 | Premier League · England |
| 2008-11-14 | NAC BredavHeraclesEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-11-14 | ChateaurouxvVannesLigue 2 · France | 1–0 | Ligue 2 · France |
| 2008-11-14 | Bristol RvsvScunthorpeLeague One · England | 1–2 | League One · England |
| 2008-11-14 | GuingampvToursLigue 2 · France | 3–1 | Ligue 2 · France |
| 2008-11-14 | BastiavLensLigue 2 · France | 0–1 | Ligue 2 · France |
| 2008-11-14 | SedanvBrestLigue 2 · France | 1–0 | Ligue 2 · France |
| 2008-11-14 | Munich 1860vAugsburg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2008-11-14 | ReimsvClermontLigue 2 · France | 1–1 | Ligue 2 · France |
| 2008-11-14 | MontpelliervTroyesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2008-11-14 | DijonvNimesLigue 2 · France | 2–1 | Ligue 2 · France |
| 2008-11-14 | St PaulivAhlen2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2008-11-14 | WesterlovGentPro League · Belgium | 3–2 | Pro League · Belgium |
| 2008-11-14 | MantovavPisaSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-11-14 | GenclerbirligivTrabzonsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2008-11-14 | BoulognevAngersLigue 2 · France | 2–3 | Ligue 2 · France |