| 2021-01-10 | RomavInterSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-01-10 | LivingstonvRoss CountyPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2021-01-10 | PAOKvVolos NFCSuper League · Greece | 3–1 | Super League · Greece |
| 2021-01-10 | Beerschot VAvGentPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-01-10 | Club AmericavAtl. San LuisLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-01-10 | UdinesevNapoliSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-01-10 | AberdeenvRangersPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-01-10 | ApollonvAsteras TripolisSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-10 | MechelenvAntwerpPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-01-10 | VascovBotafogo RJSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-01-10 | DarmstadtvHannover2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-01-10 | Tigres UANLvClub LeonLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-01-10 | RegensburgvBochum2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-01-10 | CadizvAlavesLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-01-10 | EspanolvCastellonLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-01-10 | KaragumrukvKonyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-01-10 | Arsenal SarandivHuracanCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-01-10 | VVV VenlovWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-01-10 | HataysporvBesiktasSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-01-10 | Atletico GOvBahiaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-01-10 | AugsburgvStuttgartBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2021-01-10 | AtromitosvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2021-01-10 | Argentinos JrsvBoca JuniorsCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-01-10 | BelenensesvPacos FerreiraPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-01-10 | Sparta RotterdamvFeyenoordEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-01-10 | TenerifevCartagenaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-01-10 | MallorcavLas PalmasLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-01-10 | TolucavQueretaroLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-01-10 | FortalezavGremioSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-01-10 | JuventusvSassuoloSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-01-10 | FiorentinavCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-01-10 | ValladolidvValenciaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-01-10 | AnkaragucuvBuyuksehyrSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-01-10 | VeronavCrotoneSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-10 | Viitorul ConstantavFC HermannstadtSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-01-10 | PanathinaikosvLarisaSuper League · Greece | 2–0 | Super League · Greece |
| 2021-01-10 | Sao PaulovSantosSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-01-10 | AjaxvPSV EindhovenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-01-10 | InternacionalvGoiasSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-01-10 | St TruidenvClub BruggePro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-01-10 | FarensevGil VicentePrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2021-01-10 | LevantevEibarLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-01-10 | RizesporvDenizlisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-01-10 | HeerenveenvFor SittardEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-01-10 | Oud-Heverlee LeuvenvAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-01-10 | BielefeldvHerthaBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-10 | Flamengo RJvCearaSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-01-10 | ParmavLazioSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-01-10 | PaderbornvErzgebirge Aue2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-01-10 | River PlatevIndependienteCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |