| 2021-01-16 | DortmundvMainzBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-01-16 | PalmeirasvGremioSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-01-16 | AuxerrevChateaurouxLigue 2 · France | 4–1 | Ligue 2 · France |
| 2021-01-16 | MiddlesbroughvBirminghamChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | Din. BucurestivChindia TargovisteSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-01-16 | BuyuksehyrvSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-01-16 | WolvesvWest BromPremier League · England | 2–3 | Premier League · England |
| 2021-01-16 | Ross CountyvAberdeenPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2021-01-16 | RegginavLecceSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-01-16 | Bristol RvsvCharltonLeague One · England | 0–1 | League One · England |
| 2021-01-16 | BournemouthvLutonChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | KonyasporvGoztepSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-01-16 | BurtonvIpswichLeague One · England | 0–1 | League One · England |
| 2021-01-16 | StevenagevTranmereLeague Two · England | 0–0 | League Two · England |
| 2021-01-16 | AccringtonvGillinghamLeague One · England | 0–1 | League One · England |
| 2021-01-16 | AFC WimbledonvSunderlandLeague One · England | 0–3 | League One · England |
| 2021-01-16 | CittadellavAscoliSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-01-16 | HannovervSt Pauli2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-01-16 | Newport CountyvSalfordLeague Two · England | 0–0 | League Two · England |
| 2021-01-16 | DerbyvRotherhamChampionship · England | 0–1 | Championship · England |
| 2021-01-16 | WalsallvOldhamLeague Two · England | 1–1 | League Two · England |
| 2021-01-16 | TroyesvSochauxLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-01-16 | HullvBlackpoolLeague One · England | 1–1 | League One · England |
| 2021-01-16 | WrexhamvDover AthleticNational League · England | 3–1 | National League · England |
| 2021-01-16 | OostendevKortrijkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-01-16 | WatfordvHuddersfieldChampionship · England | 2–0 | Championship · England |
| 2021-01-15 | Greuther FurthvPaderborn2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-15 | Union BerlinvLeverkusenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-15 | ChievovVirtus EntellaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-01-15 | GenclerbirligivKaragumrukSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2021-01-15 | UTA AradvViitorul ConstantaSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-01-15 | EupenvAnderlechtPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-01-15 | LaziovRomaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-01-15 | Montpellierv MonacoLigue 1 · France | 2–3 | Ligue 1 · France |
| 2021-01-15 | Wurzburger KickersvBraunschweig2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-01-15 | FCSBvAstraSuperliga · Romania | 3–0 | Superliga · Romania |
| 2021-01-15 | PortovBenficaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-01-15 | MortonvDunfermlineChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-01-15 | VicenzavFrosinoneSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-01-15 | Sp LisbonvRio AvePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-01-14 | Defensa y JusticiavAldosiviCopa De La Liga Profesional · Argentina | 4–4 | Copa De La Liga Profesional · Argentina |
| 2021-01-14 | AtromitosvLamiaSuper League · Greece | 2–1 | Super League · Greece |
| 2021-01-14 | ArsenalvCrystal PalacePremier League · England | 0–0 | Premier League · England |
| 2021-01-14 | CFR ClujvAcademica ClinceniSuperliga · Romania | 3–1 | Superliga · Romania |
| 2021-01-14 | ArisvAEKSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-14 | Willem IIvGroningenEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2021-01-14 | FC BotosanivFC ArgesSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-01-14 | HeerenveenvWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-01-14 | CorinthiansvFluminenseSerie A · Brazil | 5–0 | Serie A · Brazil |
| 2021-01-14 | TwentevAjaxEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |