| 2021-01-17 | WaalwijkvWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-01-17 | LiverpoolvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-01-17 | AjaxvFeyenoordEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-17 | VascovCoritibaSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-01-17 | GentvAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-01-17 | CrotonevBeneventoSerie A · Italy | 4–1 | Serie A · Italy |
| 2021-01-17 | GroningenvTwenteEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-01-17 | Athletico-PRvSao PauloSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-01-17 | EmpolivSalernitanaSerie B · Italy | 5–0 | Serie B · Italy |
| 2021-01-17 | Holstein KielvKarlsruhe2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-01-17 | Velez SarsfieldvRosario CentralCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2021-01-17 | OFI CretevPAOKSuper League · Greece | 0–3 | Super League · Greece |
| 2021-01-17 | FC ArgesvGaz Metan MediasSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-01-17 | AtalantavGenoaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-01-17 | Ein FrankfurtvSchalke 04Bundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-01-17 | DenizlisporvHataysporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-01-17 | BrestvRennesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-01-17 | MonterreyvClub AmericaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-01-17 | SassuolovParmaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-01-17 | NicevBordeauxLigue 1 · France | 0–3 | Ligue 1 · France |
| 2021-01-17 | Santa ClaravFamalicaoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-01-17 | CearavBragantinoSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-01-17 | InternacionalvFortalezaSerie A · Brazil | 4–2 | Serie A · Brazil |
| 2021-01-17 | RegensburgvSandhausen2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-01-17 | St TruidenvOud-Heverlee LeuvenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-01-17 | ArisvPanathinaikosSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-17 | Beerschot VAvClub BruggePro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-01-17 | SantosvBotafogo RJSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-01-17 | PescaravCremoneseSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-01-17 | VVV VenlovHeerenveenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-01-17 | AEKvAtromitosSuper League · Greece | 2–1 | Super League · Greece |
| 2021-01-17 | StrasbourgvSt EtienneLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-01-17 | Cercle BruggevStandardPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-01-17 | Yeni MalatyasporvRizesporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2021-01-17 | Gil VicentevMaritimoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-01-16 | BolognavVeronaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-01-16 | GuingampvNancyLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-01-16 | HoffenheimvBielefeldBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-01-16 | FC KolnvHerthaBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-01-16 | Sparta RotterdamvPSV EindhovenEredivisie · Netherlands | 3–5 | Eredivisie · Netherlands |
| 2021-01-16 | Queen of SthvArbroathChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-01-16 | Waasland-BeverenvWaregemPro League · Belgium | 1–5 | Pro League · Belgium |
| 2021-01-16 | HamiltonvDundee UnitedPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-01-16 | TorinovSpeziaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-01-16 | Forest GreenvPort ValeLeague Two · England | 1–1 | League Two · England |
| 2021-01-16 | Werder BremenvAugsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-01-16 | AjacciovCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-16 | BochumvNurnberg2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-01-16 | PlymouthvCreweLeague One · England | 1–1 | League One · England |
| 2021-01-16 | LarisavApollonSuper League · Greece | 0–1 | Super League · Greece |