| 2021-01-20 | VillarrealvGranadaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-01-20 | Nott'm ForestvMiddlesbroughChampionship · England | 1–2 | Championship · England |
| 2021-01-20 | GremiovAtletico-MGSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-01-20 | Botafogo RJvAtletico GOSerie A · Brazil | 1–3 | Serie A · Brazil |
| 2021-01-20 | CoritibavFluminenseSerie A · Brazil | 3–3 | Serie A · Brazil |
| 2021-01-20 | BirminghamvPrestonChampionship · England | 0–1 | Championship · England |
| 2021-01-20 | Man CityvAston VillaPremier League · England | 2–0 | Premier League · England |
| 2021-01-20 | CardiffvQPRChampionship · England | 0–1 | Championship · England |
| 2021-01-20 | NorwichvBristol CityChampionship · England | 2–0 | Championship · England |
| 2021-01-20 | KortrijkvSt TruidenPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-01-20 | BetisvCeltaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-01-20 | GalatasarayvDenizlisporSüper Lig · Turkey | 6–1 | Süper Lig · Turkey |
| 2021-01-20 | EupenvBeerschot VAPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-01-20 | Schalke 04vFC KolnBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-01-20 | Club BruggevOostendePro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-01-20 | FulhamvMan UnitedPremier League · England | 1–2 | Premier League · England |
| 2021-01-20 | BahiavAthletico-PRSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-01-20 | BielefeldvStuttgartBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-01-20 | RB LeipzigvUnion BerlinBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-20 | MechelenvStandardPro League · Belgium | 0–4 | Pro League · Belgium |
| 2021-01-20 | FreiburgvEin FrankfurtBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-01-20 | RizesporvGaziantepSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2021-01-20 | MarseillevLensLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-20 | AntwerpvCercle BruggePro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-01-20 | HuddersfieldvMillwallChampionship · England | 0–1 | Championship · England |
| 2021-01-20 | AugsburgvBayern MunichBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-01-19 | DoncastervRochdaleLeague One · England | 1–0 | League One · England |
| 2021-01-19 | WatfordvBarnsleyChampionship · England | 1–0 | Championship · England |
| 2021-01-19 | HullvAccringtonLeague One · England | 3–0 | League One · England |
| 2021-01-19 | FC VoluntarivUTA AradSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-01-19 | HarrogatevExeterLeague Two · England | 0–0 | League Two · England |
| 2021-01-19 | VicenzavChievoSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-01-19 | SouthendvCambridgeLeague Two · England | 1–2 | League Two · England |
| 2021-01-19 | SunderlandvPlymouthLeague One · England | 1–2 | League One · England |
| 2021-01-19 | TranmerevForest GreenLeague Two · England | 3–2 | League Two · England |
| 2021-01-19 | LeicestervChelseaPremier League · England | 2–0 | Premier League · England |
| 2021-01-19 | PeterborovCharltonLeague One · England | 2–1 | League One · England |
| 2021-01-19 | CadizvLevanteLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-01-19 | ReadingvCoventryChampionship · England | 3–0 | Championship · England |
| 2021-01-19 | RotherhamvStokeChampionship · England | 3–3 | Championship · England |
| 2021-01-19 | West HamvWest BromPremier League · England | 2–1 | Premier League · England |
| 2021-01-19 | CheltenhamvNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2021-01-19 | AlavesvSevillaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-01-19 | GoztepvGenclerbirligiSüper Lig · Turkey | 4–0 | Süper Lig · Turkey |
| 2021-01-19 | Milton Keynes DonsvFleetwood TownLeague One · England | 3–1 | League One · England |
| 2021-01-19 | EastleighvKings LynnNational League · England | 0–1 | National League · England |
| 2021-01-19 | M'gladbachvWerder BremenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-19 | AnderlechtvCharleroiPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-01-19 | DerbyvBournemouthChampionship · England | 1–0 | Championship · England |
| 2021-01-19 | PortsmouthvAFC WimbledonLeague One · England | 4–0 | League One · England |