| 2021-01-23 | HerthavWerder BremenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2021-01-23 | WealdstonevAldershotNational League · England | 3–4 | National League · England |
| 2021-01-23 | GironavEspanolLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-01-23 | PanathinaikosvOFI CreteSuper League · Greece | 2–0 | Super League · Greece |
| 2021-01-23 | DunfermlinevAyrChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-01-23 | RiedvAustria ViennaBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-01-23 | ExetervStevenageLeague Two · England | 3–1 | League Two · England |
| 2021-01-23 | VitessevGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-23 | Sepsi Sf. GheorghevAstraSuperliga · Romania | 4–1 | Superliga · Romania |
| 2021-01-23 | LeverkusenvWolfsburgBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-01-23 | Queen of SthvMortonChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-01-23 | Port ValevWalsallLeague Two · England | 1–3 | League Two · England |
| 2021-01-23 | St. PoltenvAdmiraBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-01-23 | FrosinonevRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-01-23 | Wolfsberger ACvHartbergBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-01-23 | Le HavrevGuingampLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-23 | St TruidenvMouscronPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-01-23 | MilanvAtalantaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-01-23 | WokingvMaidenheadNational League · England | 0–0 | National League · England |
| 2021-01-23 | MainzvRB LeipzigBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-01-23 | AugsburgvUnion BerlinBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-01-23 | BuyuksehyrvRizesporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-01-23 | CrewevAFC WimbledonLeague One · England | 1–1 | League One · England |
| 2021-01-23 | ReggianavVicenzaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-01-23 | IpswichvPeterboroLeague One · England | 0–1 | League One · England |
| 2021-01-23 | KarlsruhevHeidenheim2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-23 | Den HaagvFC EmmenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-01-23 | UTA AradvFC ArgesSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-01-23 | Notts CountyvTorquayNational League · England | 0–0 | National League · England |
| 2021-01-23 | RangersvRoss CountyPremiership · Scotland | 5–0 | Premiership · Scotland |
| 2021-01-23 | QPRvDerbyChampionship · England | 0–1 | Championship · England |
| 2021-01-23 | SuttonvEastleighNational League · England | 3–0 | National League · England |
| 2021-01-23 | PaderbornvWurzburger Kickers2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-01-23 | HeraclesvHeerenveenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-23 | CosenzavPordenoneSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-01-23 | Pau FCvTroyesLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-01-23 | U CraiovavViitorul ConstantaSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-01-23 | ClermontvAuxerreLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-23 | MalagavPonferradinaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-01-23 | OxfordvBristol RvsLeague One · England | 2–0 | League One · England |
| 2021-01-23 | HuescavVillarrealLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-01-23 | BarnetvAltrinchamNational League · England | 1–2 | National League · England |
| 2021-01-23 | CharltonvSwindonLeague One · England | 2–2 | League One · England |
| 2021-01-23 | LausannevSionSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-01-23 | Paris FCvAmiensLigue 2 · France | 4–2 | Ligue 2 · France |
| 2021-01-23 | WiganvFleetwood TownLeague One · England | 0–0 | League One · England |
| 2021-01-23 | GrenoblevChamblyLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-01-23 | OldhamvNewport CountyLeague Two · England | 3–2 | League Two · England |
| 2021-01-23 | Mazatlan FCvSantos LagunaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2021-01-23 | RomavSpeziaSerie A · Italy | 4–3 | Serie A · Italy |